发明授权
- 专利标题: 3-NITROGEN-6,7-DIOXYGEN STEROIDS AND USES RELATED THERETO
- 专利标题(中): 3 - 氮基-6,7-二氧化类固醇化合物及其用途
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申请号: EP01925262.6申请日: 2001-04-30
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公开(公告)号: EP1278763B1公开(公告)日: 2007-02-14
- 发明人: RAYMOND, Jeffery, R. , KASSERRA, Claudia, E. , SHEN, Yaping
- 申请人: Inflazyme Pharmaceuticals, Ltd.
- 申请人地址: Suite 425, 5600 Parkwood Way Richmond, British Columbia V6V 2M2 CA
- 专利权人: Inflazyme Pharmaceuticals, Ltd.
- 当前专利权人: Inflazyme Pharmaceuticals, Ltd.
- 当前专利权人地址: Suite 425, 5600 Parkwood Way Richmond, British Columbia V6V 2M2 CA
- 代理机构: Gowshall, Jonathan Vallance
- 优先权: US200617P 20000428
- 国际公布: WO2001083512 20011108
- 主分类号: C07J41/00
- IPC分类号: C07J41/00 ; C07J71/00 ; A61K31/57 ; A61K31/58 ; A61K31/56 ; A61P11/06 ; A61P37/08
摘要:
A compound of formula (I) and pharmaceutical acceptable salts, solvates, stereoisomers and prodrugs thereof, in isolation or in mixture, wherein, independently at each occurrence: R?1 and R2¿ are selected from hydrogen, oxygen so as to form nitro or oxime, amino, sulfate, and sulfonic acid, and organic groups having 1-30 carbons and optionally containing 1-6 heteroatoms selected from nitrogen, oxygen, phosphorous, silicon, and sulfur, where R?1 and R2¿ may, together with the N to which they are both bonded, form a heterocyclic structure that may be part of an organic group having 1-30 carbons and optionally containing 1-6 heteroatoms selected from nitrogen, oxygen and silicon, and where R1 may be a 2, or 3 atom chain to numeral 2 so that —N-R1 - forms part of a fused bicyclic structure to ring A; R?3 and R4¿ are selected from direct bonds to 6 and 7 respectively so as to form carbonyl groups, hydrogen, or a protecting group such that R3 and/or R4 is part of hydroxyl or carbonyl protecting group; numerals 1 through 17 each represent a carbon having substitution as described. The compounds may be formulated into pharmaceutical compositions, and used in the treatment and/or prevention of various conditions, including inflammation, asthma, an allergic disease, chronic obstructive pulmonary disease, atopic dermatitis, solid tumors, AIDS, ischemia, and cardiac arrhythmias.
公开/授权文献
- EP1278763A1 3-NITROGEN-6,7-DIOXYGEN STEROIDS AND USES RELATED THERETO 公开/授权日:2003-01-29
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