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公开(公告)号：EP1996217A2
公开(公告)日：2008-12-03
申请号：EP07752701.8
申请日：2007-03-09
IPC分类号： A61K38/16
CPC分类号： A61K38/10 , A61K2300/00
摘要： This invention is directed to antibiotic compositions comprising a targeting moiety covalently linked to an antibiotic moiety. This invention is also directed to pharmaceutical compositions comprising the antibiotic compositions of the invention and methods of making and using the antibiotic compositions of the invention.
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2.发明公开
公开(公告)号：EP1304333A2
公开(公告)日：2003-04-23
申请号：EP02025269.8
申请日：1997-07-11
发明人： Piers, Edward , Chau, Joseph, H.L , Rogers, Christine , Salari, Hassan , Burgoyne, David, L. , Shen, Yaping , Langlands, John, M.
CPC分类号： C07J71/001 , C07J1/0007 , C07J1/0011 , C07J1/0022 , C07J3/00 , C07J7/002 , C07J9/00 , C07J13/005 , C07J13/007 , C07J17/00 , C07J21/008 , C07J31/006 , C07J41/0016 , C07J51/00 , C07J71/0026
摘要： Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6α and 7β oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6α and 7β oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and δ-lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.
摘要翻译： 公开了在类固醇核上具有各种氧取代的类固醇化合物。 存在于许多类固醇化合物上的具体功能是在6和7位都是氧取代。因此，某些类固醇在C6和C7具有氧取代，并且一些具有特异性立体化学例如6α和7β氧取代， 除了具有6个α和7个β氧取代之外，在5位的α氢。 还公开了具有3,4-环氧官能团的类固醇。 此外，公开了具有C17吡喃和δ-内酯官能团的类固醇，其在类固醇核的C6和C7或C15处具有氧取代。
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公开(公告)号：EP1304333A3
公开(公告)日：2005-03-09
申请号：EP02025269.8
申请日：1997-07-11
发明人： Piers, Edward , Chau, Joseph, H.L , Rogers, Christine , Salari, Hassan , Burgoyne, David, L. , Shen, Yaping , Langlands, John, M.
IPC分类号： C07J1/00 , A61K31/56 , C07J21/00 , C07J51/00 , C07J71/00 , C07J17/00 , C07J13/00 , C07J9/00 , C07J7/00 , C07J3/00 , C07J31/00 , C07J41/00
CPC分类号： C07J71/001 , C07J1/0007 , C07J1/0011 , C07J1/0022 , C07J3/00 , C07J7/002 , C07J9/00 , C07J13/005 , C07J13/007 , C07J17/00 , C07J21/008 , C07J31/006 , C07J41/0016 , C07J51/00 , C07J71/0026
摘要： Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6α and 7β oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6α and 7β oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and δ-lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.
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4.发明授权SUBSTITUTED GAMMA-PHENYL-DELTA-LACTONES AND ANALOGS THEREOF AND USES RELATED THERETO 有权取代GAMMA苯基-δ-内酯及其模拟和用途
公开(公告)号：EP1112262B1
公开(公告)日：2004-08-04
申请号：EP99941351.1
申请日：1999-09-09
发明人： SHEN, Yaping , BURGOYNE, David, L. , LAUENER, Ronald, W. , ZHOU, Yuanlin , REBSTEIN, Patrick, J. , ABRAHAM, Samuel, D., M.
IPC分类号： C07D309/30 , C07F5/02 , C07D405/10 , C07F9/40 , C07D211/76 , A61K31/35
CPC分类号： C07F5/025 , A61K31/366 , C07D211/76 , C07D309/30 , C07F9/6552
摘要： η-Phenyl-substituted Δ-lactones and analogs thereof, including lactams, are disclosed. They may be formulated into pharmaceutical compositions, and/or used in the treatment or prevention of inflammation or other conditions or disease states.
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公开(公告)号：EP0917534B1
公开(公告)日：2002-12-04
申请号：EP97929071.5
申请日：1997-07-11
发明人： BURGOYNE, David, L. , SHEN, Yaping , LANGLANDS, John, M. , ROGERS, Christine , CHAU, Joseph, H.-L. , PIERS, Edward , SALARI, Hassan
CPC分类号： C07J9/00 , C07J1/0007 , C07J1/0011 , C07J1/0022 , C07J3/00 , C07J7/002 , C07J13/005 , C07J13/007 , C07J17/00 , C07J21/008 , C07J31/006 , C07J41/0016 , C07J51/00 , C07J71/001 , C07J71/0026 , Y02P20/55 , Y10S514/825 , Y10S514/826
摘要： Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6 alpha and 7 beta oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6 alpha and 7 beta oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and delta -lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.
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6.发明公开SUBSTITUTED $g(g)-PHENYL-$g(D)-LACTONES AND ANALOGS THEREOF AND USES RELATED THERETO 有权取代GAMMA苯基-δ-内酯及其模拟和用途
公开(公告)号：EP1112262A1
公开(公告)日：2001-07-04
申请号：EP99941351.1
申请日：1999-09-09
发明人： SHEN, Yaping , BURGOYNE, David, L. , LAUENER, Ronald, W. , ZHOU, Yuanlin , REBSTEIN, Patrick, J. , ABRAHAM, Samuel, D., M.
IPC分类号： C07D309/30 , C07F5/02 , C07D405/10 , C07F9/40 , C07D211/76 , A61K31/35
CPC分类号： C07F5/025 , A61K31/366 , C07D211/76 , C07D309/30 , C07F9/6552
摘要： η-Phenyl-substituted Δ-lactones and analogs thereof, including lactams, are disclosed. They may be formulated into pharmaceutical compositions, and/or used in the treatment or prevention of inflammation or other conditions or disease states.
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公开(公告)号：EP0917534A2
公开(公告)日：1999-05-26
申请号：EP97929071.0
申请日：1997-07-11
发明人： BURGOYNE, David, L. , SHEN, Yaping , LANGLANDS, John, M. , ROGERS, Christine , CHAU, Joseph, H.-L. , PIERS, Edward , SALARI, Hassan
IPC分类号： A61K31 , C07J1 , C07J3 , C07J7 , C07J9 , C07J13 , C07J17 , C07J21 , C07J31 , C07J41 , C07J51 , C07J71
CPC分类号： C07J9/00 , C07J1/0007 , C07J1/0011 , C07J1/0022 , C07J3/00 , C07J7/002 , C07J13/005 , C07J13/007 , C07J17/00 , C07J21/008 , C07J31/006 , C07J41/0016 , C07J51/00 , C07J71/001 , C07J71/0026 , Y02P20/55 , Y10S514/825 , Y10S514/826
摘要： Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6α and 7β oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6α and 7β oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and δ-lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.
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8.发明公开SUBSTITUTED BENZYLAMINES AS CYP2A INHIBITORS AND USES THEREOF TO TREAT NICOTINE DEPENDENCE 审中-公开取代，如苄CYP2A抑制剂及其使用尼古丁依赖治疗
公开(公告)号：EP1871357A2
公开(公告)日：2008-01-02
申请号：EP06740741.1
申请日：2006-04-06
发明人： GHOSHEH, Omar , RAYMOND, Jeff
IPC分类号： A61K31/341 , C07D307/04
CPC分类号： A61K31/537
摘要： This invention is directed to substitued benzylamines which are useful as inhibitors of the CYP2A6 enzyme. Pharmaceutical compositions comprising the compounds and methods of using the compounds to treat nicotine dependence are also disclosed.
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公开(公告)号：EP1278763B1
公开(公告)日：2007-02-14
申请号：EP01925262.6
申请日：2001-04-30
CPC分类号： C07J41/00 , C07J41/0005 , C07J41/0011 , C07J43/00 , C07J71/0047 , C07J71/0063 , Y02P20/55
摘要： A compound of formula (I) and pharmaceutical acceptable salts, solvates, stereoisomers and prodrugs thereof, in isolation or in mixture, wherein, independently at each occurrence: R?1 and R2¿ are selected from hydrogen, oxygen so as to form nitro or oxime, amino, sulfate, and sulfonic acid, and organic groups having 1-30 carbons and optionally containing 1-6 heteroatoms selected from nitrogen, oxygen, phosphorous, silicon, and sulfur, where R?1 and R2¿ may, together with the N to which they are both bonded, form a heterocyclic structure that may be part of an organic group having 1-30 carbons and optionally containing 1-6 heteroatoms selected from nitrogen, oxygen and silicon, and where R1 may be a 2, or 3 atom chain to numeral 2 so that —N-R1 - forms part of a fused bicyclic structure to ring A; R?3 and R4¿ are selected from direct bonds to 6 and 7 respectively so as to form carbonyl groups, hydrogen, or a protecting group such that R3 and/or R4 is part of hydroxyl or carbonyl protecting group; numerals 1 through 17 each represent a carbon having substitution as described. The compounds may be formulated into pharmaceutical compositions, and used in the treatment and/or prevention of various conditions, including inflammation, asthma, an allergic disease, chronic obstructive pulmonary disease, atopic dermatitis, solid tumors, AIDS, ischemia, and cardiac arrhythmias.
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公开(公告)号：EP1615866A1
公开(公告)日：2006-01-18
申请号：EP04727484.0
申请日：2004-04-15
发明人： RAYMOND, Jeffery, R. , HAN, Kang , ZHOU, Yuanlin , HE, Yuehua , NOREN, Bradley , YEE, James, Gee, Ken
IPC分类号： C07C35/21 , C07C35/32 , C07C35/52 , C07C69/03 , C07C215/42 , C07C233/18 , C07C279/08 , C07C311/04 , C07D213/30 , C07D233/56 , A61K31/047 , A61K31/133 , A61K31/155 , A61K31/164 , A61K31/18
CPC分类号： C07C35/32 , C07C35/14 , C07C35/21 , C07C51/083 , C07C51/347 , C07C62/34 , C07C69/013 , C07C213/00 , C07C213/08 , C07C215/42 , C07C233/18 , C07C233/21 , C07C233/72 , C07C247/14 , C07C279/08 , C07C311/04 , C07C315/00 , C07C2601/14 , C07C2602/08 , C07C2602/24 , C07D207/335 , C07D211/58 , C07D213/30 , C07D213/38 , C07D213/74 , C07D233/54 , C07D233/64 , C07D295/096 , C07D307/66 , C07D317/66 , C07D317/70 , Y10S514/825 , Y10S514/826 , Y10S514/863
摘要： Compounds of formula (Ia): wherein R1, R2, R3, R4a, R4b, R5 and R6 are defined herein, as well as other indene derivatives are disclosed herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译： 式（Ia）化合物：其中R1，R2，R3，R4a，R4b，R5和R6如本文所定义，以及其它茚衍生物在本文中公开。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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