发明公开
EP1280527A2 USE OF SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES IN THE TREATMENT OF TUMORS ASSOCIATED WITH HIGH LEVELS OF GLUTATHIONE
有权
取代偏端霉素ACRYLOYLDERIVATEN肿瘤与治疗用量增加谷胱甘肽水平有关
- 专利标题： USE OF SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES IN THE TREATMENT OF TUMORS ASSOCIATED WITH HIGH LEVELS OF GLUTATHIONE
- 专利标题（中）： 取代偏端霉素ACRYLOYLDERIVATEN肿瘤与治疗用量增加谷胱甘肽水平有关
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申请号： EP01933856.5申请日： 2001-04-19
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公开(公告)号： EP1280527A2公开(公告)日： 2003-02-05
- 发明人: GERONI, Maria, Cristina, Rosa , COZZI, Paolo , BERIA, Italo
- 申请人： Pharmacia Italia S.p.A.
- 申请人地址： Via Robert Koch 1.2 20152 Milano IT
- 专利权人： Pharmacia Italia S.p.A.
- 当前专利权人： Pharmacia Italia S.p.A.
- 当前专利权人地址： Via Robert Koch 1.2 20152 Milano IT
- 优先权： GB0011059 20000508
- 国际公布： WO01085144 20011115
- 主分类号： A61K31/4025
- IPC分类号： A61K31/4025 ; A61K31/4155 ; A61K31/4178 ; A61P35/00 ; A61K45/06
摘要：
Compounds which are α-halogenoacryloyl distamycin derivatives of formula (I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies.
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