发明公开
- 专利标题: THROMBOMODULIN ANALOGS FOR PHARMACEUTICAL USE
- 专利标题(中): 血栓调节蛋白类似物和它们的药物用途
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申请号: EP01948487.2申请日: 2001-06-20
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公开(公告)号: EP1292673A2公开(公告)日: 2003-03-19
- 发明人: LIGHT, David , MORSER, Michael, John , NAGASHIMA, Mariko
- 申请人: SCHERING AKTIENGESELLSCHAFT
- 申请人地址: 13342 Berlin DE
- 专利权人: SCHERING AKTIENGESELLSCHAFT
- 当前专利权人: SCHERING AKTIENGESELLSCHAFT
- 当前专利权人地址: 13342 Berlin DE
- 代理机构: Ziebig, Marlene, Dr. Dipl.-Chem.
- 优先权: US213678P 20000621; US880484 20010612
- 国际公布: WO01098352 20011227
- 主分类号: C12N15/00
- IPC分类号: C12N15/00 ; C07K14/745 ; A61K38/36 ; C12N15/12 ; A61K31/713
摘要:
The present invention relates to the design, production and use of analogs of thrombomodulin (TM) that have the ability to enhance the thrombin-mediated activation of protein C but which have a significantly reduced ability to promote activation of thrombin-activatable fibrinolysis inhibitor (TAFI). These analogs are useful in, for example, antithrombotic therapy.
公开/授权文献
- EP1292673B1 THROMBOMODULIN ANALOGS FOR PHARMACEUTICAL USE 公开/授权日:2005-11-09
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