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公开(公告)号：EP0527821A1
公开(公告)日：1993-02-24
申请号：EP91908593.0
申请日：1991-04-09
CPC分类号： C12N9/6459 , A61K38/00 , C07K14/7455 , C12Y304/21069
摘要： On a produit de nouveaux analogues de thrombomoduline solubles résistant à l'oxydation et destinés à divers emplois thérapeutiques et autres , tels que dans des thérapies de maladies thrombotiques et vasculaires. Ces analogues présentent les propriétés thérapeutiques caractéristiques de la thrombomoduline native, cependant ils sont solubles et ils ne sont pas inactivés après avoir éte exposés à des oxydants. Certains des analogues de l'invention sont des protéines de fusion multifonctionnelles présentant à la fois une activité anti-thrombotique et une certaine bioactivité supplémentaire.
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公开(公告)号：EP1292673B1
公开(公告)日：2005-11-09
申请号：EP01948487.2
申请日：2001-06-20
IPC分类号： C12N15/00 , C07K14/745 , A61K38/36 , C12N15/12 , A61K31/713
CPC分类号： C07K14/7455 , A61K38/00
摘要： The present invention relates to the design, production and use of analogs of thrombomodulin (TM) that have the ability to enhance the thrombin-mediated activation of protein C but which have a significantly reduced ability to promote activation of thrombin-activatable fibrinolysis inhibitor (TAFI). These analogs are useful in, for example, antithrombotic therapy.
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公开(公告)号：EP1084259A1
公开(公告)日：2001-03-21
申请号：EP99927888.0
申请日：1999-06-04
发明人： MORSER, Michael, John , WU, Qingyu , YAN, Wei
CPC分类号： C12N9/6424
摘要： The present invention relates to a corin polypeptide which contains one or more frizzled corin and possesses various activities, including, e.g., serin protease activity and a pro-ANF converting activity, LDLR, SRCR repeats, serine protease catalytic domains such as human and mouse corin. The invention further relates to methods of using such nucleic acids and polypeptides in therapeutics, diagnostics, and research. For example, the nucleic acids and polypeptides of corin can be utilized in methods to identify modulators of its activity, in animal models to mimic human disease, and to treat kidney, cardiovascular, and other conditions in which corin is involved.
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公开(公告)号：EP1292673A2
公开(公告)日：2003-03-19
申请号：EP01948487.2
申请日：2001-06-20
IPC分类号： C12N15/00 , C07K14/745 , A61K38/36 , C12N15/12 , A61K31/713
CPC分类号： C07K14/7455 , A61K38/00
摘要： The present invention relates to the design, production and use of analogs of thrombomodulin (TM) that have the ability to enhance the thrombin-mediated activation of protein C but which have a significantly reduced ability to promote activation of thrombin-activatable fibrinolysis inhibitor (TAFI). These analogs are useful in, for example, antithrombotic therapy.
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公开(公告)号：EP0998583A1
公开(公告)日：2000-05-10
申请号：EP98933580.7
申请日：1998-06-02
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Polymorphisms within a plasma carboxypeptidase designated plasma carboxypeptidase B (PCPB) have been identified. The relative distribution of these polymorphs in a patient's blood can be used to assess an indivudual's risk toward thrombotic disease.
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公开(公告)号：EP1365788A2
公开(公告)日：2003-12-03
申请号：EP01973674.3
申请日：2001-08-31
IPC分类号： A61K38/00
CPC分类号： A61K38/366
摘要： The present invention relates to the use thrombomodulin analogs for the treatment of trauma-induced spinal cord injury.
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公开(公告)号：EP1100910A1
公开(公告)日：2001-05-23
申请号：EP99939418.2
申请日：1999-07-23
CPC分类号： C07K14/4703 , A61K38/00 , A61K48/00
摘要： The present invention relates to novel human inhibitor-of-apoptosis polypeptides, designated HIAP3, polynucleotides encoding the polypeptides, methods for producing the polypeptides, expression vectors and genetically engineered host cells for expression of the polypeptides. The invention further relates to methods for utilizing the polynucleotides and polypeptides in research, diagnosis, and therapeutic applications.
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公开(公告)号：EP0527821B1
公开(公告)日：1997-05-21
申请号：EP91908593.6
申请日：1991-04-09
IPC分类号： C07K14/745 , A61K38/36 , C12N15/12
CPC分类号： C12N9/6459 , A61K38/00 , C07K14/7455 , C12Y304/21069
摘要： Novel soluble oxidation resistant thrombomodulin analogs are produced for various therapeutic and other uses, such as in thrombotic and vascular disease therapies. These analogs exhibit the characteristic therapeutic properties of native thrombomodulin, yet they are soluble and are not inactivated after they have been exposed to oxidants. Some of the analogs disclosed are multifunctional fusion proteins having both antithrombotic activity and some additional bioactivity.
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