发明公开
EP1293214A3 LTB4 antagonists and radiopharmaceuticals for imaging infection and inflammation
失效
成像感染和炎症LTB4拮抗剂和放射性药物
- 专利标题： LTB4 antagonists and radiopharmaceuticals for imaging infection and inflammation
- 专利标题（中）： 成像感染和炎症LTB4拮抗剂和放射性药物
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申请号： EP02079932.6申请日： 1997-10-06
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公开(公告)号： EP1293214A3公开(公告)日： 2003-03-26
- 发明人: Barret, John Andrew , Cheesman, Edward Hollister , Harris, Thomas David , Rajopadhye, Milind
- 申请人： Bristol-Myers Squibb Pharma Company
- 申请人地址： PO Box 4000 Princeton, New Jersey 08443-4000 US
- 专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人： Bristol-Myers Squibb Pharma Company
- 当前专利权人地址： PO Box 4000 Princeton, New Jersey 08443-4000 US
- 代理机构： Howard, Paul Nicholas
- 优先权： US726507 19961007
- 主分类号： A61K51/04
- IPC分类号： A61K51/04 ; C07D405/04 ; C07D213/82
摘要：
The present invention provides novel radiopharmaceutials useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis. The radiopharmaceuticals bind in vivo to the leukotriene B4 (LTB4) receptor on the surface of leukocytes which accumulate at the site of infection and inflammation. The reagents provided by this invention are also useful for the treatment of diseases associated with infection and inflammation.
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