公开(公告)号：EP1772452A3

公开(公告)日：2007-07-04

申请号：EP06076915.5

申请日：2001-02-15

申请人： Bristol-Myers Squibb Pharma Company

发明人： Decicco, Carl P. ,  Nelson, David J. ,  Barrett, John A. ,  Carpenter, Alan P. ,  Duran, James J. ,  Rajopadhye, Milind

IPC分类号： C07D413/12 ,  C07D267/00 ,  C07D401/12 ,  C07D401/14 ,  C07F9/09 ,  A61K31/395 ,  A61K31/4427 ,  A61K31/661 ,  A61K51/04 ,  A61P35/00 ,  A61P29/00

CPC分类号： A61K49/14 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/10 ,  A61K51/088 ,  C07D207/26 ,  C07D213/82 ,  C07D267/00 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07F9/6527

摘要： The present invention describes novel compounds comprising: 1-10 targeting moieties; a chelator (Ch); and 0-1 linking groups (Ln) between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to a cytotoxic radioisotope. The present invention also provides novel compositions of the compounds of the invention, kits, and their uses in treatment of diseases associated with MMPs.

公开(公告)号：EP1293214A3

公开(公告)日：2003-03-26

申请号：EP02079932.6

申请日：1997-10-06

申请人： Bristol-Myers Squibb Pharma Company

发明人： Barret, John Andrew ,  Cheesman, Edward Hollister ,  Harris, Thomas David ,  Rajopadhye, Milind

IPC分类号： A61K51/04 ,  C07D405/04 ,  C07D213/82

CPC分类号： C07D213/64 ,  A61K51/0497 ,  C07C69/734 ,  C07C323/41 ,  C07D213/77 ,  C07D213/82 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07H15/12

摘要： The present invention provides novel radiopharmaceutials useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis. The radiopharmaceuticals bind in vivo to the leukotriene B4 (LTB4) receptor on the surface of leukocytes which accumulate at the site of infection and inflammation. The reagents provided by this invention are also useful for the treatment of diseases associated with infection and inflammation.

公开(公告)号：EP1293214A2

公开(公告)日：2003-03-19

申请号：EP02079932.6

申请日：1997-10-06

申请人： Bristol-Myers Squibb Pharma Company

发明人： Barret, John Andrew ,  Cheesman, Edward Hollister ,  Harris, Thomas David ,  Rajopadhye, Milind

IPC分类号： A61K51/04 ,  C07D405/04 ,  C07D213/82

CPC分类号： C07D213/64 ,  A61K51/0497 ,  C07C69/734 ,  C07C323/41 ,  C07D213/77 ,  C07D213/82 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07H15/12

摘要： The present invention provides novel radiopharmaceutials useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis. The radiopharmaceuticals bind in vivo to the leukotriene B4 (LTB4) receptor on the surface of leukocytes which accumulate at the site of infection and inflammation. The reagents provided by this invention are also useful for the treatment of diseases associated with infection and inflammation.

摘要翻译： 本发明提供了可用于诊断感染和炎症的新型放射性药物，可用于制备放射性药物的试剂和试剂盒，成像患者感染和/或炎症部位成像方法，以及诊断患者感染或炎症相关疾病的方法 需要这样的诊断。 放射性药物在体内结合白细胞表面的白细胞三烯B4（LTB4）受体，其在感染和炎症部位积聚。 本发明提供的试剂也可用于治疗与感染和炎症相关的疾病。

公开(公告)号：EP1772452A2

公开(公告)日：2007-04-11

申请号：EP06076915.5

申请日：2001-02-15

申请人： Bristol-Myers Squibb Pharma Company

发明人： Decicco, Carl P. ,  Nelson, David J. ,  Barrett, John A. ,  Carpenter, Alan P. ,  Duran, James J. ,  Rajopadhye, Milind

IPC分类号： C07D401/12 ,  C07D413/12 ,  C07D267/00 ,  C07D401/14 ,  C07F9/09 ,  A61K31/395 ,  A61K31/4427 ,  A61K31/661 ,  A61K51/04

CPC分类号： A61K49/14 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/10 ,  A61K51/088 ,  C07D207/26 ,  C07D213/82 ,  C07D267/00 ,  C07D401/12 ,  C07D401/14 ,  C07D413/12 ,  C07F9/6527

摘要： The present invention describes novel compounds comprising: 1-10 targeting moieties; a chelator (Ch); and 0-1 linking groups (Ln) between the targeting moiety and chelator; wherein the targeting moiety is a matrix metalloproteinase inhibitor; and wherein the chelator is capable of conjugating to a cytotoxic radioisotope. The present invention also provides novel compositions of the compounds of the invention, kits, and their uses in treatment of diseases associated with MMPs.

摘要翻译： 本发明描述了新颖化合物，其包含：1-10个靶向部分; 螯合剂（Ch）; 和靶向部分和螯合剂之间的0-1个连接基团（Ln）; 其中靶向部分是基质金属蛋白酶抑制剂; 并且其中所述螯合剂能够结合至细胞毒性放射性同位素。 本发明还提供本发明化合物，试剂盒及其在治疗与MMP相关的疾病中的用途的新型组合物。