发明公开
- 专利标题： NOVEL THERAPEUTIC MOLECULAR VARIANTS AND USES THEREOF
- 专利标题（中）： 治疗性MOLEKULÄRE变化及其用途
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申请号： EP01942904.2申请日： 2001-06-20
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公开(公告)号： EP1299548A1公开(公告)日： 2003-04-09
- 发明人: PITSON, Stuart , MORETTI, Paul , XIA, Pu , VADAS, Matthew , WATTENBERG, Binks
- 申请人： MEDVET SCIENCE PTY. LTD.
- 申请人地址： 20 Dalgleish Street Thebarton, S.A. 5031 AU
- 专利权人： MEDVET SCIENCE PTY. LTD.
- 当前专利权人： MEDVET SCIENCE PTY. LTD.
- 当前专利权人地址： 20 Dalgleish Street Thebarton, S.A. 5031 AU
- 代理机构： Jones, Elizabeth Louise
- 优先权： AUPP840800 20000628; AUPP869900 20000711; AUPP998000 20000908; AUPP274901 20010129
- 国际公布： WO02000887 20020103
- 主分类号： C12N15/54
- IPC分类号： C12N15/54 ; C12N9/10 ; C12Q1/48 ; A61K38/45
摘要：
The present invention relates generally to a sphingosine kinase variant and to derivatives, analogues, chemical equivalents and mimetics thereof exhibiting reduced catalytic activity and, more particularly, to sphingosine kinase variants which exhibit a reduced capacity to phosphorylate sphingosine to sphingosine-1-phosphate. The present invention also contemplates genetic sequences encoding said sphingosine kinase variants and derivatives, analogues and mimetics thereof. The variants of the present invention are useful in a range of therapeutic and prophylactic applications.
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