公开(公告)号：EP1299548A1

公开(公告)日：2003-04-09

申请号：EP01942904.2

申请日：2001-06-20

申请人： MEDVET SCIENCE PTY. LTD.

发明人： PITSON, Stuart ,  MORETTI, Paul ,  XIA, Pu ,  VADAS, Matthew ,  WATTENBERG, Binks

IPC分类号： C12N15/54 ,  C12N9/10 ,  C12Q1/48 ,  A61K38/45

CPC分类号： C12N9/1205 ,  A61K38/00 ,  C12Y207/01091 ,  G01N2333/91205 ,  G01N2500/02 ,  G01N2500/04

摘要： The present invention relates generally to a sphingosine kinase variant and to derivatives, analogues, chemical equivalents and mimetics thereof exhibiting reduced catalytic activity and, more particularly, to sphingosine kinase variants which exhibit a reduced capacity to phosphorylate sphingosine to sphingosine-1-phosphate. The present invention also contemplates genetic sequences encoding said sphingosine kinase variants and derivatives, analogues and mimetics thereof. The variants of the present invention are useful in a range of therapeutic and prophylactic applications.

公开(公告)号：EP0904293A1

公开(公告)日：1999-03-31

申请号：EP97921538.0

申请日：1997-05-23

申请人： BresaGen Limited ,  MEDVET SCIENCE PTY. LTD.

发明人： LOPEZ, Angel ,  VADAS, Matthew ,  SHANNON, Frances ,  BASTIRAS, Stan ,  HEY, Allan, William

IPC分类号： C12N15 ,  A61K38 ,  A61P11 ,  A61P37 ,  C07K1 ,  C07K14 ,  C12P21 ,  C12R1

CPC分类号： C07K1/1133 ,  A61K38/00 ,  C07K14/5409

摘要： The present invention relates to modified and variant forms of Interleukin-5 molecules capable of antagonizing or reducing the activity of IL-5 and their use in ameliorating, abating or otherwise reducing the aberrant effects caused by native or mutant forms of IL-5.