发明公开
EP1307216A1 POLYMER-MODIFIED BIOACTIVE SYNTHETIC CHEMOKINES, AND METHODS FOR THEIR MANUFACTURE AND USE
审中-公开
聚合物改性的生物活性合成趋化因子和制备方法和用途FOR THEIR
- 专利标题： POLYMER-MODIFIED BIOACTIVE SYNTHETIC CHEMOKINES, AND METHODS FOR THEIR MANUFACTURE AND USE
- 专利标题（中）： 聚合物改性的生物活性合成趋化因子和制备方法和用途FOR THEIR
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申请号： EP01952656.5申请日： 2001-07-12
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公开(公告)号： EP1307216A1公开(公告)日： 2003-05-07
- 发明人: KOCHENDOERFER, Gerd , BOTTI, Paolo , BRADBURNE, James, A. , CHEN, Shiah-yun , CRESSMAN, Sonya
- 申请人： Gryphon Therapeutics, Inc.
- 申请人地址： 250 East Grand Avenue South San Francisco, CA 94080-4824 US
- 专利权人： Gryphon Therapeutics, Inc.
- 当前专利权人： Gryphon Therapeutics, Inc.
- 当前专利权人地址： 250 East Grand Avenue South San Francisco, CA 94080-4824 US
- 代理机构： Micheli & Cie
- 优先权： US217683P 20000712
- 国际公布： WO02004015 20020117
- 主分类号： A61K38/19
- IPC分类号： A61K38/19
摘要：
The invention relates to polymer-modified bioactive synthetic chemokines and to methods for their production and use. The bioactive synthetic chemokines of the invention comprises a polymer modified polypeptide chemokine backbone. The compounds and methods or the invention are useful for the treatment of disorders involving naturally occurring chemokines, such as for the treatment of HIV and AIDS related disorders and for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, organ transplant rejection, and rheumatoid arthritis.
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