公开(公告)号：EP1315513A2

公开(公告)日：2003-06-04

申请号：EP01952657.3

申请日：2001-07-12

申请人： Gryphon Therapeutics, Inc.

发明人： KENT, Stephen, B., H. ,  BOTTI, Paolo ,  LOW, Donald, W. ,  BRADBURNE, James, A. ,  HUNTER, Christie, L. ,  CHEN, Shiah-yun ,  CRESSMAN, Sonya ,  KOCHENDOERFER, Gerd

IPC分类号： A61K38/02 ,  A61K38/18 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K38/27 ,  C07K1/02 ,  C07K2/00 ,  C07K14/475 ,  C07K14/505 ,  C07K14/52 ,  C07K14/525 ,  C07K14/535 ,  C07K14/54 ,  C07K14/555 ,  C07K14/575

CPC分类号： C07K14/505 ,  A61K38/00

摘要： The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see Figure 1). The invention further provides methods and uses for such proteins and derivatized proteins. The invention is particularly suitable for use in the synthesis of optionally polymer-modified, synthetic bioactive proteins, and of pharmaceutical compositions that contain such proteins.

公开(公告)号：EP1616021A2

公开(公告)日：2006-01-18

申请号：EP03814988.6

申请日：2003-12-30

申请人： Gryphon Therapeutics, Inc.

发明人： KOCHENDOERFER, Gerd, G. ,  SHAO, Haiyan ,  CRESSMAN, Sonya

IPC分类号： C12Q1/00 ,  G01N33/53 ,  C07K14/00

CPC分类号： C07K1/1077 ,  C07K1/023 ,  C07K1/047 ,  C07K1/1072 ,  C07K14/535 ,  Y02P20/55

摘要： The invention concerns a multiplex polymer ligation method involving water-soluble polymeric protecting groups, compositions and methods of use. The method involves synthesis of a first compound bearing one or more water-soluble polymeric protecting groups followed by replacing one or more of the water-soluble protecting groups with a chemical adduct of interest. Multiple different compounds derived from the first compound can be readily prepared by splitting the first compound into first and second reaction systems, followed by replacing one or more of the water-soluble polymeric protecting groups of the first reaction system with a first chemical adduct, and replacing one or more of the water-soluble polymeric protecting groups of the second reaction system with a second chemical adduct of interest, where the first and second chemical adducts are different. Also provided are kits useful for carrying out the multiplex polymer ligation methods of the invention.

公开(公告)号：EP1307216A1

公开(公告)日：2003-05-07

申请号：EP01952656.5

申请日：2001-07-12

申请人： Gryphon Therapeutics, Inc.

发明人： KOCHENDOERFER, Gerd ,  BOTTI, Paolo ,  BRADBURNE, James, A. ,  CHEN, Shiah-yun ,  CRESSMAN, Sonya

IPC分类号： A61K38/19

CPC分类号： C07K14/7158 ,  A61K38/00 ,  A61K47/60 ,  A61K47/62

摘要： The invention relates to polymer-modified bioactive synthetic chemokines and to methods for their production and use. The bioactive synthetic chemokines of the invention comprises a polymer modified polypeptide chemokine backbone. The compounds and methods or the invention are useful for the treatment of disorders involving naturally occurring chemokines, such as for the treatment of HIV and AIDS related disorders and for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, organ transplant rejection, and rheumatoid arthritis.

公开(公告)号：EP1318827A1

公开(公告)日：2003-06-18

申请号：EP01952654.0

申请日：2001-07-12

申请人： Gryphon Therapeutics, Inc.

发明人： KOCHENDOERFER, Gerd, G. ,  LOW, Donald, W. ,  BOTTI, Paolo ,  WILKEN, Jill, G. ,  BRADBURNE, James, A. ,  CHEN, Shiah-yun ,  CRESSMAN, Sonya ,  HUNTER, Christie, L. ,  KENT, Stephen, B., H.

IPC分类号： A61K38/02 ,  A61K38/18 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  C07K1/113 ,  C07K1/13 ,  C07K2/00 ,  C07K14/475

CPC分类号： C07K14/505 ,  A61K38/00

摘要： The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides methods and uses for such polymer-modified peptides, polypeptides and proteins. The invention is particularly suitable for use in the synthesis of polymer-modified synthetic bioactive proteins (Figure 1D), and of pharmaceutical compositions that contain such proteins.

公开(公告)号：EP1315511A2

公开(公告)日：2003-06-04

申请号：EP01957133.0

申请日：2001-07-12

申请人： Gryphon Therapeutics, Inc.

发明人： KOCHENDOERFER, Gerd ,  BOTTI, Paolo ,  BRADBURNE, James, A. ,  CHEN, Shiah-yun ,  CRESSMAN, Sonya ,  HUNTER, Christie, L. ,  KENT, Stephen, B.H. ,  LOW, Donald, W.

IPC分类号： A61K38/00 ,  C07K1/00 ,  C07K14/505

CPC分类号： C07K14/505 ,  A61K38/00

摘要： Synthetic erythropoiesis stimulating proteins are provided. Also provided are methods for synthesizing the proteins. The invention further relates to derivatives of such synthetic erythropoiesis stimulating proteins that are polymer-modified in a defined manner. Methods and uses for such proteins and derivatized proteins are also provided.