发明公开
- 专利标题： ANTICONVULSANT DERIVATIVES USEFUL FOR THE TREATMENT OF DEPRESSION
- 专利标题（中）： 镇惊衍生物对抑郁症的治疗
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申请号： EP01959293.0申请日： 2001-07-27
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公开(公告)号： EP1309325A1公开(公告)日： 2003-05-14
- 发明人: PLATA-SALAMAN, Carlos , BACALTCHUK, Josue , PRADO-LIMA, Pedro, A., S.
- 申请人： Ortho-McNeil Pharmaceutical, Inc.
- 申请人地址： U.S. Route No.202,P.O. Box 300 Raritan, NJ 08869-0602 US
- 专利权人： Ortho-McNeil Pharmaceutical, Inc.
- 当前专利权人： Ortho-McNeil Pharmaceutical, Inc.
- 当前专利权人地址： U.S. Route No.202,P.O. Box 300 Raritan, NJ 08869-0602 US
- 代理机构： Mercer, Christopher Paul
- 优先权： US222489P 20000802
- 国际公布： WO02009694 20020207
- 主分类号： A61K31/255
- IPC分类号： A61K31/255 ; A61K31/35 ; A61K31/7048 ; A61P25/24
摘要：
Anticonvulsant derivatives of formula (I) for the treating depression as monotherapy or combination therapy are disclosed. Wherein X is CH2 or oxygen; R1 is hydrogen or alkyl; and R?2, R3, R4 and R5¿ are independently hydrogen or lower alkyl and, when X is CH¿2?, R?4 and R5¿ may be alkene groups joined to form a benzene ring and, when X is oxygen, R?2 and R3¿ and/or R?4 and R5¿ together may be a methylenedioxy group of the following formula (II): wherein R?6 and R7¿ are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.
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