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1.发明授权
公开(公告)号：EP1446394B1
公开(公告)日：2006-11-02
申请号：EP02776448.9
申请日：2002-11-04
发明人： EISINGER, Magdalena , FITZPATRICK, Louis, J. , LEE, Daniel, H. , PAN, Kevin , PLATA-SALAMAN, Carlos , REITZ, Allen, B. , SMITH-SWINTOSKY, Virginia, L. , ZHAO, Boyu
IPC分类号： C07D285/08 , C07D417/12 , A61K31/433 , A61P3/00 , A61P17/00 , A61P25/00
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D417/12
摘要： The present invention is directed to novel 1,2,4-thiadiazole derivatives of the formula (II) wherein R1, R2 and R4, are ring containing radicals, useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders.
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2.发明公开TREATMENT OF DEMENTIA AND MEMORY DISORDERS WITH ANTICONVULSANTS AND ACETYLCHOLINESTERASE INHIBITORS 审中-公开痴呆和记忆问题的抗惊厥药和乙酰胆碱酯酶治疗
公开(公告)号：EP1423127A1
公开(公告)日：2004-06-02
申请号：EP02757450.8
申请日：2002-08-28
CPC分类号： A61K31/255 , A61K31/35 , A61K31/36 , A61K31/55 , A61K31/70 , A61K2300/00
摘要： The present invention describes therapy for the treatment of dementia, memory disorders and the behavioral, psychiatric and/or psychological manifestations or symptoms associated with dementia or a memory disorder comprising co-therapy with a therapeutically effective amount of one or more acetylcholinesterase inhibitors with one or more anticonvulsant derivatives.
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公开(公告)号：EP1296702A1
公开(公告)日：2003-04-02
申请号：EP01941562.9
申请日：2001-05-23
发明人： SMITH-SWINTOSKY, Virginia , RENZI, Michael , PLATA-SALAMAN, Carlos , JOLLIFFE, Linda , FARRELL, Francis , JOHNSON, Dana, L.
CPC分类号： C07K14/505 , A61K38/00
摘要： Methods of treating diseases of the nervous system by administration of compositions having the neurological therapeutic activity of human erythropoietin are disclosed. These compositions include therapeutic agents such as peptides, peptide dimers, polypeptides, and proteins that have the full range of biological activity of human erythropoietin or only certain biological activities of erythropoietin. Improved therapeutic regimens where the erythropoietin is administered at concentrations below those required to stimulate hematopoiesis are also provided.
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4.发明授权
公开(公告)号：EP1444215B1
公开(公告)日：2006-07-19
申请号：EP02778727.4
申请日：2002-11-05
发明人： EISINGER, Magdalena , FITZPATRICK, Louis, J. , LEE, Daniel, H. , PAN, Kevin , PLATA-SALAMAN, Carlos , REITZ, Allen, B. , SMITH-SWINTOSKY, Virginia, L. , ZHAO, Boyu
IPC分类号： C07D285/08 , C07D417/12 , A61K31/433 , A61P3/00 , A61P17/00 , A61P25/00
CPC分类号： C07D285/08 , A61K8/49 , A61Q5/006 , A61Q19/00 , A61Q19/007 , C07D333/16 , C07D417/12 , C07F9/4018
摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives of the formula (I); wherein R?1, R2 and R4¿ are ring containing radicals, R3 is H, alkyl, alkenyl or alkynyl, useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatement of metabolic, CNS and dermatological disorders.
摘要翻译： 本发明涉及式（I）的新型1,2,4-噻二唑-2-鎓衍生物; 其中R 1，R 2和R 4'是含有基团的环，R 3是H，烷基，烯基或炔基，用作黑皮质素受体的激动剂或拮抗剂。 更具体地说，本发明的化合物可用于治疗代谢，CNS和皮肤疾病。
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5.发明授权
公开(公告)号：EP1309324B1
公开(公告)日：2006-03-22
申请号：EP01958878.9
申请日：2001-07-06
IPC分类号： A61K31/255 , A61K31/35 , A61K31/7048 , A61P3/10 , A61P5/50
CPC分类号： A61K31/36 , A61K31/255 , A61K31/35 , A61K31/357 , A61K31/7048
摘要： Anticonvulsant derivatives of formula (I) useful for preventing the development of Type II diabetes mellitus and Syndrome X are disclosed. Wherein X is CH 2 or oxygen; R1 is hydrogen or alkyl; and R?2, R3, R4 and R5¿ are independently hydrogen or lower alkyl and when X is CH¿2?, R?4 and R5¿ may be alkene groups joined to form a benzene ring and, when X is oxygen, R?2 and R3¿ and/or R?4 and R5¿ together may be a methylenedioxy group of the following formula (II) : wherein R?6 and R7¿ are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.
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公开(公告)号：EP1309325A1
公开(公告)日：2003-05-14
申请号：EP01959293.0
申请日：2001-07-27
IPC分类号： A61K31/255 , A61K31/35 , A61K31/7048 , A61P25/24
CPC分类号： A61K31/7048 , A61K31/255 , A61K31/35 , A61K31/357 , A61K31/7024
摘要： Anticonvulsant derivatives of formula (I) for the treating depression as monotherapy or combination therapy are disclosed. Wherein X is CH2 or oxygen; R1 is hydrogen or alkyl; and R?2, R3, R4 and R5¿ are independently hydrogen or lower alkyl and, when X is CH¿2?, R?4 and R5¿ may be alkene groups joined to form a benzene ring and, when X is oxygen, R?2 and R3¿ and/or R?4 and R5¿ together may be a methylenedioxy group of the following formula (II): wherein R?6 and R7¿ are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.
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7.发明公开
公开(公告)号：EP1309324A2
公开(公告)日：2003-05-14
申请号：EP01958878.9
申请日：2001-07-06
IPC分类号： A61K31/255 , A61K31/35 , A61K31/7048 , A61P3/10 , A61P5/50
CPC分类号： A61K31/36 , A61K31/255 , A61K31/35 , A61K31/357 , A61K31/7048
摘要： Anticonvulsant derivatives of formula (I) useful for preventing the development of Type II diabetes mellitus and Syndrome X are disclosed. Wherein X is CH 2 or oxygen; R1 is hydrogen or alkyl; and R?2, R3, R4 and R5¿ are independently hydrogen or lower alkyl and when X is CH¿2?, R?4 and R5¿ may be alkene groups joined to form a benzene ring and, when X is oxygen, R?2 and R3¿ and/or R?4 and R5¿ together may be a methylenedioxy group of the following formula (II) : wherein R?6 and R7¿ are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.
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