专利检索 ap:("Ortho-McNeil Pharmaceutical, Inc.") AND inv:"BACALTCHUK, Josue" 第 1 页

1.

发明公开
ANTICONVULSANT DERIVATIVES USEFUL FOR THE TREATMENT OF DEPRESSION 审中-公开
标题翻译：镇惊衍生物对抑郁症的治疗

公开(公告)号：EP1309325A1

公开(公告)日：2003-05-14

申请号：EP01959293.0

申请日：2001-07-27

申请人： Ortho-McNeil Pharmaceutical, Inc.

发明人： PLATA-SALAMAN, Carlos , BACALTCHUK, Josue , PRADO-LIMA, Pedro, A., S.

IPC分类号： A61K31/255 , A61K31/35 , A61K31/7048 , A61P25/24

CPC分类号： A61K31/7048 , A61K31/255 , A61K31/35 , A61K31/357 , A61K31/7024

摘要： Anticonvulsant derivatives of formula (I) for the treating depression as monotherapy or combination therapy are disclosed. Wherein X is CH2 or oxygen; R1 is hydrogen or alkyl; and R?2, R3, R4 and R5¿ are independently hydrogen or lower alkyl and, when X is CH¿2?, R?4 and R5¿ may be alkene groups joined to form a benzene ring and, when X is oxygen, R?2 and R3¿ and/or R?4 and R5¿ together may be a methylenedioxy group of the following formula (II): wherein R?6 and R7¿ are the same or different and are hydrogen, lower alkyl or are alkyl and are joined to form a cyclopentyl or cyclohexyl ring.