发明公开
- 专利标题: METHOD OF MONITORING THE EFFECT OF CATHEPSIN S INHIBITORS
- 专利标题(中): 监测方法组织蛋白酶S抑制剂的作用
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申请号: EP01968093申请日: 2001-08-24
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公开(公告)号: EP1315966A4公开(公告)日: 2005-07-27
- 发明人: THURMOND ROBIN , SUN SIQUAN , KARLSSON LARS
- 申请人: ORTHO MCNEIL PHARM INC
- 专利权人: ORTHO MCNEIL PHARM INC
- 当前专利权人: ORTHO MCNEIL PHARM INC
- 优先权: US23048400 2000-09-06
- 主分类号: G01N33/53
- IPC分类号: G01N33/53 ; C12Q1/37 ; G01N33/573 ; G01N33/535 ; G01N33/545
摘要:
The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed patients.
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