公开(公告)号：EP1315966A4

公开(公告)日：2005-07-27

申请号：EP01968093

申请日：2001-08-24

申请人： ORTHO MCNEIL PHARM INC

发明人： THURMOND ROBIN ,  SUN SIQUAN ,  KARLSSON LARS

IPC分类号： G01N33/53 ,  C12Q1/37 ,  G01N33/573 ,  G01N33/535 ,  G01N33/545

CPC分类号： G01N33/573 ,  C12Q1/37 ,  G01N2333/8139 ,  G01N2333/96466 ,  Y10S435/962 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/825 ,  Y10T436/25125 ,  Y10T436/25375

摘要： The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed patients.