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公开(公告)号：EP1675606A4
公开(公告)日：2009-09-30
申请号：EP04781153
申请日：2004-08-13
CPC分类号： C07K14/524 , A61K38/00 , A61K47/60
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公开(公告)号：EP1211933A4
公开(公告)日：2005-01-05
申请号：EP00959222
申请日：2000-08-14
发明人： LEUNG WAI-PING , YANG YOUNG , PRECKEL TOBIAS
IPC分类号： A01K67/027 , C07K14/47 , C12N5/10 , C12N15/09 , C12N15/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/075 , C07K14/4702
摘要： A transgenic mouse with alterations in a PA28 beta gene is prepared by introduction of an altered PA28 beta gene into a host mouse. The resulting transgenic animals do not produce functional PA28 molecules. Cells and cell lines derived from these animals also contain the altered PA28 beta gene.
摘要翻译： 通过将改变的PA28beta基因导入宿主小鼠来制备具有PA28beta基因改变的转基因小鼠。 所得转基因动物不产生功能性PA28分子。 衍生自这些动物的细胞和细胞系也含有改变的PA28beta基因。
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公开(公告)号：EP1294929A4
公开(公告)日：2004-12-29
申请号：EP01946127
申请日：2001-06-06
发明人： JOHNSON DANA L , EMANUEL STUART L
CPC分类号： C12Q1/485 , C07K14/71 , C07K2319/00
摘要： The present invention relates to assays for the detection of compounds with pharmacological activity, particularly for the detection of modulators of rat vascular endothelial growth factor receptor (rat VEGF-R2) kinase domain.
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4.发明公开IMPROVED ANTI-VIRAL AND ANTI-TUMOR CHEMOTHERAPY BY ADMINISTRATION OF ERYTHROPOEITIN 审中-公开改进的抗病毒和抗肿瘤的化疗通过给予促红细胞生成素
公开(公告)号：EP1325324A4
公开(公告)日：2004-11-10
申请号：EP01959497
申请日：2001-08-01
发明人： ITRI LORETTA , BOWERS PETER
IPC分类号： G01N33/72 , A61K31/7052 , A61K31/7056 , A61K31/7072 , A61K38/18 , A61K38/21 , A61K38/22 , A61K45/00 , A61P7/06 , A61P25/00 , A61P31/18 , A61P31/20 , A61P35/00 , A61P43/00 , G01N33/15 , A61K31/70
CPC分类号： A61K38/21 , A61K38/1816 , A61K38/14 , A61K33/24 , A61K31/70 , A61K31/675 , A61K31/505 , A61K31/475 , A61K31/415 , A61K31/195 , A61K2300/00
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5.发明公开EX-VIVO PRIMING FOR GENERATING CYTOTOXIC T LYMPHOCYTES SPECIFIC FOR NON-TUMOR ANTIGENS TO TREAT AUTOIMMUNE AND ALLERGIC DISEASE 有权EX体内引发一种生成细胞，而不是肿瘤抗原的T淋巴细胞特异性自身免疫性疾病和过敏性疾病的治疗
公开(公告)号：EP1407004A4
公开(公告)日：2004-07-21
申请号：EP02769746
申请日：2002-05-13
发明人： CAI ZELING , JACKSON MICHAEL R , PETERSON PER A , SHI WEIXING , KONG YAN , DEGRAW JULI
IPC分类号： C12N15/09 , A61K39/00 , A61P3/10 , A61P11/02 , A61P11/06 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/02 , A61P37/08 , C12N5/0783 , C12N5/08 , A01N63/00
CPC分类号： A61K39/0008 , A61K2035/122 , C12N5/0636 , C12N2501/23 , C12N2501/51 , C12N2501/58 , C12N2502/50 , C12N2502/99
摘要： Cytotoxic T lymphocytes (CTLs) specific for antigenic peptides derived from IgE molecules can be generated in vitro by stimulating resting naive CD8 T+ cells with IgE peptides presented by artificial antigen presenting cells. The IgE specific CTLs lyse the target cells loaded with IgE peptides in vitro and inhibit antigen specific IgE responses in vivo . In addition, adoptive transfer of the IgE specific CTLs to an asthmatic mouse model can inhibit the development of lung inflammation and airway hypersensitivity. IgE specific CTLs provide a treatment for allergic asthma and other IgE-mediated allergic diseases. Antigenic peptides identified from non-tumor self-antigens induce specific cytotoxic T lymphocytes (CTLs) in vitro. The CTLs induced by peptides identified from CD40L can kill activated CD4+ T cells. In vitro generated CTLs specific for CD40L inhibit CD4-dependent antibody responses of all isotypes in vivo. In contrast, CTLs induced by antigenic peptides derived from IgE specifically inhibit IgE responses, and adoptive transfer of CD40L-specific CTL to NOD mice at early age delay the development of diabetes in NOD mice. In vitro generated CTLs specific for non-tumor self-antigens expressed on activated CD4+ T cells regulate immune responses in vivo .
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公开(公告)号：EP1181036A4
公开(公告)日：2004-04-21
申请号：EP00921929
申请日：2000-04-07
发明人： CHEUNG WING K , NATARAJAN JAYA , SANDERS MARILYN , VERCAMEN ELS , SHARMA BASANT , BEGUN SELIMA
IPC分类号： A61K47/04 , A61K9/00 , A61K38/18 , A61K38/22 , A61K47/00 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/18 , A61K47/26 , A61K47/42 , A61P7/06 , A61P7/08 , A61K38/16
CPC分类号： A61K9/0019 , A61K38/1816 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/42
摘要： The present invention provides aqueous pharmaceutical formulations of erythropoietin that are free of human serum blood products, stabilized with a quantity of an amino acid and a sorbitan mono-9-octadecenoate poly(oxy-1,2-ethanediyl) derivative. The present invention also provides aqueous stable, preserved pharmaceutical formulations of erythropoietin that contain an antimicrobial quantity of cresol and a quantity of an amino acid.
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公开(公告)号：EP1617807A4
公开(公告)日：2007-02-21
申请号：EP04760305
申请日：2004-04-21
发明人： LU TIANBAO , MILKIEWICZ KAREN L , RABOISSON PIERRE , CUMMINGS MAXWELL DAVID , CALVO RAUL R , PARKS DANIEL J , LAFRANCE LOUIS V III , MARUGAN SANCHEZ JUAN JOSE , GUSHUE JOAN , LEONARD KRISTI
IPC分类号： C07D243/14 , A61K20060101 , A61K31/55 , A61P35/00 , A61P37/02 , C07D405/06 , H04L12/56
CPC分类号： C07D243/14 , C07D405/06 , H04L45/02 , H04L45/245 , H04L45/50 , H04L47/50 , Y02D50/30
摘要： At the provider edge of a core network, an egress interface may schedule based on a class dominance model, a destination dominance model or a herein-proposed class-destination dominance model. In the latter, queues are organized into sub-divisions, where each of the subdivisions includes a subset of the queues having a per hop behavior in common and at least one of the subsets of the queues is further organized into a group of queues storing protocol data units having a common destination. Scheduling may then be performed on a destination basis first, then a per hop behavior basis. Thus providing user-awareness to a normally user-unaware class dominance scheduling model.
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8.发明公开
公开(公告)号：EP1487446A4
公开(公告)日：2006-04-19
申请号：EP03719363
申请日：2003-03-07
发明人： PFAHL MAGNUS , TACHDJIAN CATHERINE , AL-SHAMMA HUSSIEN A , GIACHINO ANDREA FANJUL , JAKUBOWICZ-JAILLARDON KARINE , GUO JIANHUA , FINE RICHARD M , SPRUCE LYLE W , ZAPF JAMES W
IPC分类号： C07D277/34 , C07D417/08 , A61K31/426 , A61K31/427 , A61P3/00 , A61P3/06 , A61P3/10 , A61P35/00 , C07D277/20 , C07D277/36 , C07D417/06 , C07D417/10 , C07D417/14
CPC分类号： C07D277/20 , C07D417/06 , C07D417/10 , C07D417/14
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9.发明公开
公开(公告)号：EP1326961A4
公开(公告)日：2005-11-09
申请号：EP01968626
申请日：2001-09-06
IPC分类号： G01N33/53 , A61K35/14 , A61K39/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/08 , C07K14/725 , C12N5/0783 , C12N5/10 , C12N15/09 , C12Q1/02 , G01N33/50 , C12N5/00 , A61K39/38 , C12N5/02
CPC分类号： C12N5/0636 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , C12N2501/23 , C12N2501/52 , C12N2502/11 , G01N33/505
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公开(公告)号：EP1296702A4
公开(公告)日：2005-05-11
申请号：EP01941562
申请日：2001-05-23
发明人： SMITH-SWINTOSKY VIRGINIA , RENZI MICHAEL , PLATA-SALAMAN CARLOS , JOLLIFFE LINDA , FARRELL FRANCIS , JOHNSON DANA L
IPC分类号： A61K47/48 , A61K38/00 , A61P7/02 , A61P7/04 , A61P7/06 , A61P9/10 , A61P13/02 , A61P13/12 , A61P17/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/02 , A61P43/00 , C07K7/08 , C07K14/505 , C07K2/00 , C07K5/00 , C07K7/00
CPC分类号： C07K14/505 , A61K38/00
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