发明公开
- 专利标题: WERKSTOFF ZUR HERSTELLUNG VON ERZEUGNISSEN MIT FIBRINOLYTISCHEN UND/ODER ANTIBAKTERIELLEN EIGENSCHAFTEN
- 专利标题(英): Material for producing products having fibrinolytic and/or antibacterial properties
- 专利标题(中): 材料对产品的纤维蛋白溶解和/或抗菌特性上的制造
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申请号: EP01982122.2申请日: 2001-09-19
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公开(公告)号: EP1328306A2公开(公告)日: 2003-07-23
- 发明人: SCHUNK, Werner , BRUDER, Michael , GIESSMANN, Konrad , KRAUSE, Karl-Heinz , MERKMANN, Gerhard
- 申请人: Intech Thüringen GmbH
- 申请人地址: Eisenacher Landstrasse 70 99880 Waltshausen DE
- 专利权人: Intech Thüringen GmbH
- 当前专利权人: Intech Thüringen GmbH
- 当前专利权人地址: Eisenacher Landstrasse 70 99880 Waltshausen DE
- 优先权: DE10050317 20001010
- 国际公布: WO02030388 20020418
- 主分类号: A61M1/14
- IPC分类号: A61M1/14
摘要:
The invention relates to a material for producing products (1) having fibrinolytic and/or antibacterial properties. Said material has at least one matrix (2), which is compatible with body tissue and in which a molecular sieve is incorporated. Said molecular sieve is loaded with: at least one active substance (Z) having a fibrinolytic or antibacterial effect; or at least one first active substance (Z1) having a fibrinolytic effect and a second active substance (Z2) having an antibacterial effect. The corresponding molecular sieve/active substance adduct (3) releases the active substance(s) in conjunction with the aqueous body fluid when the matrix (2) is in contact with the body tissue (4). The inventive material is characterized in that the molecular sieve/active substance adduct (3) additionally contains water of crystallization to such an extent that the molecular sieve is partially dehydrated with regard to a sufficient basic molar quantity (m) of water of crystallization. The molecular sieve is loaded with the reduced molar quantity (m') of water of crystallization with the active substance(s) (Z, Z1, Z2) so that an adsorption of water with the desorption of the corresponding active substance occurs when the matrix (2) is in contact with the body tissue (4), whereby the water of crystallization of the molecular sieve increases. The invention also relates to an advantageous method for producing the inventive active substance.
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