发明授权
- 专利标题： MACROLIDES
- 专利标题（中）： 大环内酯类
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申请号： EP01982656.9申请日： 2001-10-19
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公开(公告)号： EP1328535B1公开(公告)日： 2007-08-15
- 发明人: ALIHODZIC, Suleman Pliva d.d. , BERDIK, Andrea Pliva d.d. , CARDULLO, Francesca GlaxoSmithKline SpA , HUTINEC, Antun Pliva d.d. , LAZAREVSKI, Gorjana Pliva d.d. , LOCIURO, Sergio GlaxoSmithKline SpA , MARUSIC-ISTUK, Zorica Pliva d.d. , MUTAK, Stjepan Pliva d.d. , POZZAN, Alfonso GlaxoSmithKline SpA , DEREK, Marko Pliva d.d.
- 申请人： GLAXO GROUP LIMITED , GlaxoSmithKline istrazivacki centar Zagreb d.o.o.
- 申请人地址： Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 ONN GB
- 专利权人： GLAXO GROUP LIMITED,GlaxoSmithKline istrazivacki centar Zagreb d.o.o.
- 当前专利权人： GLAXO GROUP LIMITED,GlaxoSmithKline istrazivacki centar Zagreb d.o.o.
- 当前专利权人地址： Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 ONN GB
- 代理机构： Giddings, Peter John
- 优先权： GB0025688 20001019
- 国际公布： WO2002032917 20020425
- 主分类号： C07H17/08
- IPC分类号： C07H17/08 ; A61K31/70 ; A61P31/04
摘要：
The present invention relates to a compound of formula (I) wherein R1 is hydrogen or together with R2 is oxo; R2 represents hydroxy, OC(O)XR7, OC(O)NHXR7 or R2 together with R1 is an oxo group; R3 is hydrogen or a hydroxyl protecting group; R4 is hydrogen or XR7; R5 is hydrogen, XR7 or C(O)NHXR7; R6 is hydrogen or R5 and R6 taken together with the intervening atoms form a cyclic carbonate having the following structure and pharmaceutically acceptable salts and solvates thereof and solvates thereof; to processes for their preparation and their use in the therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.
公开/授权文献
- EP1328535A1 MACROLIDES 公开/授权日：2003-07-23
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