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公开(公告)号：EP1328535B1
公开(公告)日：2007-08-15
申请号：EP01982656.9
申请日：2001-10-19
发明人： ALIHODZIC, Suleman Pliva d.d. , BERDIK, Andrea Pliva d.d. , CARDULLO, Francesca GlaxoSmithKline SpA , HUTINEC, Antun Pliva d.d. , LAZAREVSKI, Gorjana Pliva d.d. , LOCIURO, Sergio GlaxoSmithKline SpA , MARUSIC-ISTUK, Zorica Pliva d.d. , MUTAK, Stjepan Pliva d.d. , POZZAN, Alfonso GlaxoSmithKline SpA , DEREK, Marko Pliva d.d.
摘要： The present invention relates to a compound of formula (I) wherein R1 is hydrogen or together with R2 is oxo; R2 represents hydroxy, OC(O)XR7, OC(O)NHXR7 or R2 together with R1 is an oxo group; R3 is hydrogen or a hydroxyl protecting group; R4 is hydrogen or XR7; R5 is hydrogen, XR7 or C(O)NHXR7; R6 is hydrogen or R5 and R6 taken together with the intervening atoms form a cyclic carbonate having the following structure and pharmaceutically acceptable salts and solvates thereof and solvates thereof; to processes for their preparation and their use in the therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.
摘要翻译： 本发明涉及式（I）的化合物，其中R 1为氢或与R 2一起为氧代; R2代表羟基，OC（O）XR7，OC（O）NHXR7或R2与R1一起为氧代基; R3是氢或羟基保护基; R4是氢或XR7; R5是氢，XR7或C（O）NHXR7; R6是氢或R5和R6与插入的原子一起形成具有以下结构的环状碳酸酯及其药学上可接受的盐和溶剂合物及其溶剂合物; 其制备方法及其在治疗或预防人体或动物体内全身或局部细菌感染中的用途。
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2.发明授权AZABICYCLO[3.1.0]HEXANE DERIVAIVES AS DOPAMIN D3 RECEPTOR MODULATORS 有权氮杂双环[3.1.0]己烷衍生物作为多巴胺D 3受体的调节剂
公开(公告)号：EP1891057B1
公开(公告)日：2010-10-27
申请号：EP06743165.0
申请日：2006-06-13
申请人： GLAXO GROUP LIMITED
发明人： ARISTA, Luca GlaxoSmithKline SpA , CARDULLO, Francesca GlaxoSmithKline SpA , CHECCHIA, Anna GlaxoSmithKline SpA , HAMPRECHT, Dieter GlaxoSmithKline SpA , MICHELI, Fabrizio GlaxoSmithKline SpA , TEDESCO, Giovanna GlaxoSmithKline SpA , TERRENI, Silvia GlaxoSmithKline
IPC分类号： C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D413/14 , C07D401/14 , A61K31/435 , A61K31/41 , A61P25/00
CPC分类号： C07D417/14 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to novel compounds of formula (I) or pharmaceutically acceptable salt thereof: (I), processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, premature ejaculation or cognition impairment.
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3.发明公开AZAB I CYCLO [3 . 1 . 0] HEXANE DERIVATIVES AS DOPAMIN D3 RECEPTOR MODULATORS 有权氮杂双环[3.1.0]己烷衍生物作为多巴胺D 3受体的调节剂
公开(公告)号：EP1891057A1
公开(公告)日：2008-02-27
申请号：EP06743165.0
申请日：2006-06-13
申请人： GLAXO GROUP LIMITED
发明人： ARISTA, Luca GlaxoSmithKline SpA , CARDULLO, Francesca GlaxoSmithKline SpA , CHECCHIA, Anna GlaxoSmithKline SpA , HAMPRECHT, Dieter GlaxoSmithKline SpA , MICHELI, Fabrizio GlaxoSmithKline SpA , TEDESCO, Giovanna GlaxoSmithKline SpA , TERRENI, Silvia GlaxoSmithKline
IPC分类号： C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D413/14 , C07D401/14 , A61K31/435 , A61K31/41 , A61P25/00
CPC分类号： C07D417/14 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to novel compounds of formula (I) or pharmaceutically acceptable salt thereof: (I), processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, premature ejaculation or cognition impairment.
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