公开(公告)号：EP1328535B1

公开(公告)日：2007-08-15

申请号：EP01982656.9

申请日：2001-10-19

申请人： GLAXO GROUP LIMITED ,  GlaxoSmithKline istrazivacki centar Zagreb d.o.o.

发明人： ALIHODZIC, Suleman Pliva d.d. ,  BERDIK, Andrea Pliva d.d. ,  CARDULLO, Francesca GlaxoSmithKline SpA ,  HUTINEC, Antun Pliva d.d. ,  LAZAREVSKI, Gorjana Pliva d.d. ,  LOCIURO, Sergio GlaxoSmithKline SpA ,  MARUSIC-ISTUK, Zorica Pliva d.d. ,  MUTAK, Stjepan Pliva d.d. ,  POZZAN, Alfonso GlaxoSmithKline SpA ,  DEREK, Marko Pliva d.d.

IPC分类号： C07H17/08 ,  A61K31/70 ,  A61P31/04

CPC分类号： C07H17/08 ,  Y02P20/55

摘要： The present invention relates to a compound of formula (I) wherein R1 is hydrogen or together with R2 is oxo; R2 represents hydroxy, OC(O)XR7, OC(O)NHXR7 or R2 together with R1 is an oxo group; R3 is hydrogen or a hydroxyl protecting group; R4 is hydrogen or XR7; R5 is hydrogen, XR7 or C(O)NHXR7; R6 is hydrogen or R5 and R6 taken together with the intervening atoms form a cyclic carbonate having the following structure and pharmaceutically acceptable salts and solvates thereof and solvates thereof; to processes for their preparation and their use in the therapy or prophylaxis of systemic or topical bacterial infections in a human or animal body.

摘要翻译： 本发明涉及式（I）的化合物，其中R 1为氢或与R 2一起为氧代; R2代表羟基，OC（O）XR7，OC（O）NHXR7或R2与R1一起为氧代基; R3是氢或羟基保护基; R4是氢或XR7; R5是氢，XR7或C（O）NHXR7; R6是氢或R5和R6与插入的原子一起形成具有以下结构的环状碳酸酯及其药学上可接受的盐和溶剂合物及其溶剂合物; 其制备方法及其在治疗或预防人体或动物体内全身或局部细菌感染中的用途。