发明公开
- 专利标题： Thiazol-2-yl-imine compounds as PDE-7 inhibitors
- 专利标题（中）： 噻唑-5-基 - 亚胺基PDE7-抑制素
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申请号： EP02290787.7申请日： 2002-03-28
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公开(公告)号： EP1348433A1公开(公告)日： 2003-10-01
- 发明人: Vergne, Fabrice , Bernardelli, Patrick , Lorthiois, Edwige , Ducrot, Pierre
- 申请人： Warner-Lambert Company LLC
- 申请人地址： 201 Tabor Road Morris Plains, New Jersey 07950 US
- 专利权人： Warner-Lambert Company LLC
- 当前专利权人： Warner-Lambert Company LLC
- 当前专利权人地址： 201 Tabor Road Morris Plains, New Jersey 07950 US
- 代理机构： Hirsch, Denise
- 主分类号： A61K31/426
- IPC分类号： A61K31/426 ; C07D277/42 ; C07D417/04 ; A61K31/427 ; A61P37/00
摘要：
A compound selected from those of formula (I):
wherein:
R 1 represents cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, which are optionally substituted as defined in the description,
R 2 represents alkyl, alkenyl, alkynyl, aryl or cycloalkyl group,
R 3 represents cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, which are optionally substituted by halogen, nitro, cyano, trifluoromethyl, oxo, alkyl, OR 6 , NR 6 R 7 , COR 6 , CO 2 R 6 , CONHOH, CONR 6 R 7 , -S(O) m R 6 , -S(O) m -NR 6 R 7 , -NR 6 COR 7 , -NR 6 SO 2 R 7 , -N(SO 2 R 7 ) 2 , -NR 6 -CO-NR 7 R 8 , and tetrazolyl, wherein m, R 6 , R 7 and R 8 , are as defined in the description,
and optionally, its optical isomers , N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of phosphosdiesterase-7 (PDE7).
wherein:
R 1 represents cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, which are optionally substituted as defined in the description,
R 2 represents alkyl, alkenyl, alkynyl, aryl or cycloalkyl group,
R 3 represents cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, which are optionally substituted by halogen, nitro, cyano, trifluoromethyl, oxo, alkyl, OR 6 , NR 6 R 7 , COR 6 , CO 2 R 6 , CONHOH, CONR 6 R 7 , -S(O) m R 6 , -S(O) m -NR 6 R 7 , -NR 6 COR 7 , -NR 6 SO 2 R 7 , -N(SO 2 R 7 ) 2 , -NR 6 -CO-NR 7 R 8 , and tetrazolyl, wherein m, R 6 , R 7 and R 8 , are as defined in the description,
and optionally, its optical isomers , N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of phosphosdiesterase-7 (PDE7).
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