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    Thiazol-2-yl-imine compounds as PDE-7 inhibitors
    1.
    发明公开
    Thiazol-2-yl-imine compounds as PDE-7 inhibitors 审中-公开
    噻唑-5-基 - 亚胺基PDE7-抑制素

    公开(公告)号：EP1348433A1

    公开(公告)日：2003-10-01

    申请号：EP02290787.7

    申请日：2002-03-28

    申请人： Warner-Lambert Company LLC

    发明人： Vergne, Fabrice ,  Bernardelli, Patrick ,  Lorthiois, Edwige ,  Ducrot, Pierre

    IPC分类号： A61K31/426 ,  C07D277/42 ,  C07D417/04 ,  A61K31/427 ,  A61P37/00

    CPC分类号： C07D417/04 ,  C07D277/42

    摘要： A compound selected from those of formula (I):
    wherein:

    R 1 represents cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, which are optionally substituted as defined in the description,
    R 2 represents alkyl, alkenyl, alkynyl, aryl or cycloalkyl group,
    R 3 represents cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, which are optionally substituted by halogen, nitro, cyano, trifluoromethyl, oxo, alkyl, OR 6 , NR 6 R 7 , COR 6 , CO 2 R 6 , CONHOH, CONR 6 R 7 , -S(O) m R 6 , -S(O) m -NR 6 R 7 , -NR 6 COR 7 , -NR 6 SO 2 R 7 , -N(SO 2 R 7 ) 2 , -NR 6 -CO-NR 7 R 8 , and tetrazolyl, wherein m, R 6 , R 7 and R 8 , are as defined in the description,
    and optionally, its optical isomers , N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of phosphosdiesterase-7 (PDE7).

    摘要翻译： 选自式（I）的化合物：其中：R 1表示环烷基，杂环烷基，芳基或杂芳基，其如说明书中所定义，任选被取代，R 2表示烷基，烯基，炔基，芳基或环烷基， 硝基，氰基，三氟甲基，氧代，烷基，OR 6，NR 6 R 7，COR 6，CO 2 R 6，CONHOH，CONR 6 R 7，-S（O）m R 6，-S（ O）m -NR 6 R 7，-NR 6 COR 7，-NR 6 SO 2 R 7，-N（SO 2 R 7）2，-NR 6 -CO-NR 7 R 8和四唑基，其中m，R 6，R 7和R 8如说明书中所定义， 异构体，N-氧化物及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物可用作磷酸二酯酶-7（PDE7）的特异性抑制剂。

    (2,4-disubstituted-thiazol-5-yl) amine compounds as PDE7 inhibitors
    4.
    发明公开
    (2,4-disubstituted-thiazol-5-yl) amine compounds as PDE7 inhibitors 审中-公开
    2,4-二取代噻唑-5-基 - 胺的PDE7-抑制剂

    公开(公告)号：EP1348701A1

    公开(公告)日：2003-10-01

    申请号：EP02290788.5

    申请日：2002-03-28

    申请人： Warner-Lambert Company LLC

    发明人： Vergne, Fabrice ,  Bernardelli, Patrick ,  Lorthiois, Edwige ,  Ducrot, Pierre

    IPC分类号： C07D277/42 ,  C07D417/04 ,  A61K31/426 ,  A61K31/427

    CPC分类号： C07D417/04 ,  C07D277/42

    摘要： A compound selected from those of formula (I):
    wherein:

    R 1a represents hydrogen, alkyl, or arylalkyl group,
    R 1b represents cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, which are optionally substituted as defined in the description,
    R 2 represents alkyl, alkenyl, alkynyl, aryl or cycloalkyl group,
    R 3 represents cycloalkyl, heterocycloalkyl, aryl or heteroaryl group, which are optionally substituted by halogen, nitro, cyano, trifluoromethyl, oxo, alkyl, OR 6 , NR 6 R 7 , COR 6 , CO 2 R 6 , CONHOH, CONR 6 R 7 , -S(O) m R 6 , -S(O) m -NR 6 R 7 , -NR 6 COR 7 , -NR 6 SO 2 R 7 , -N(SO 2 R 7 ) 2 , -NR 6 -CO-NR 7 R 8 , and tetrazolyl, wherein m, R 6 , R 7 and R_, are as defined in the description,
    and optionally, its optical isomers , N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of phosphosdiesterase-7 (PDE-7).

    摘要翻译： 选自式（I）的化合物：其中：R 1a表示氢，烷基或芳基烷基，R 1b表示环烷基，杂环烷基，芳基或杂芳基，其如说明书中所定义任选被取代，R 2表示烷基 硝基，氰基，三氟甲基，氧代，烷基，OR 6，NR 6 R 7，COR 6，CO 2 R 6，CONHOH，CONR 6 R 7， -S（O）m R 6，-S（O）m -NR 6 R 7，-NR 6 COR 7，-NR 6 SO 2 R 7，-N（SO 2 R 7）2，-NR 6 -CO-NR 7 R 8和四唑基，其中m，R 6，R 7和R 8为 并且任选地，其光学异构体，N-氧化物及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物可用作磷酸二酯酶-7（PDE-7）的特异性抑制剂。