发明公开
EP1360898A1 JOINT UTILIZATION OF THE INSULIN GENE AND THE GLUCOKINASE GENE IN THE DEVELOPMENT OF THERAPEUTIC APPROACHES FOR DIABETES MELLITUS
审中-公开
GLEICHZEITIGE VERWENDUNG DES INSULIN- UND DES GLUCOKINASEGENS BEI DER ENTWICKLUNG VONTHERAPIEANSÄTZENFÜRDIABETES MELLITUS
- 专利标题： JOINT UTILIZATION OF THE INSULIN GENE AND THE GLUCOKINASE GENE IN THE DEVELOPMENT OF THERAPEUTIC APPROACHES FOR DIABETES MELLITUS
- 专利标题（中）： GLEICHZEITIGE VERWENDUNG DES INSULIN- UND DES GLUCOKINASEGENS BEI DER ENTWICKLUNG VONTHERAPIEANSÄTZENFÜRDIABETES MELLITUS
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申请号： EP01271144.6申请日： 2001-12-19
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公开(公告)号： EP1360898A1公开(公告)日： 2003-11-12
- 发明人: BOSCH TUBERT, Fatima , RIU PASTOR, Efren , OTAEGUI GOYA, Pedro, Jose , FERRE MASFERRER, MA DEL TURA , MAS MONTEYS, Alejandro
- 申请人： UNIVERSITAT AUTONOMA DE BARCELONA
- 申请人地址： 08193 Bellaterra ES
- 专利权人： UNIVERSITAT AUTONOMA DE BARCELONA
- 当前专利权人： UNIVERSITAT AUTONOMA DE BARCELONA
- 当前专利权人地址： 08193 Bellaterra ES
- 代理机构： Ponti Sales, Adelaida
- 优先权： ES200003056 20001220
- 国际公布： WO02049423 20020627
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; C12N15/52 ; C12N15/85 ; C12N15/86 ; C12N5/10 ; A61K48/00
摘要：
This invention relates to a double transgenic animal that simultaneously expresses the gene or the cDNA (complementary DNA) of insulin and the gene or the cDNA (complementary DNA) of glucokinase directed by a promoter or fusion of promoters which permit insulin and glucokinase to be expressed in muscle and its use in the development of therapeutic approximations for diabetes mellitus.
This invention also relates to a vector or vectors of expression which permits the expression of said chimeric genes jointly in muscle cells. Said vectors can be a plasmid, a viral vector or a non-viral vector.
This invention also relates to a vector or vectors of expression which permits the expression of said chimeric genes jointly in muscle cells. Said vectors can be a plasmid, a viral vector or a non-viral vector.
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