发明公开
EP1363875A2 NOVEL BENZAMIDINE DERIVATIVES HAVING ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITY
有权
BENZAMIDINDERIVATE MITENTZÜNDUNGSHEMMENDERUND IMMUNSUPPRESSIVER WIRKUNG
- 专利标题: NOVEL BENZAMIDINE DERIVATIVES HAVING ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITY
- 专利标题(中): BENZAMIDINDERIVATE MITENTZÜNDUNGSHEMMENDERUND IMMUNSUPPRESSIVER WIRKUNG
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申请号: EP02718096.7申请日: 2002-02-06
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公开(公告)号: EP1363875A2公开(公告)日: 2003-11-26
- 发明人: MAKOVEC, Francesco , ZANZOLA, Simona , ARTUSI, Roberto , ROVATI, Lucio, Claudio
- 申请人: ROTTA RESEARCH LABORATORIUM S.P.A.
- 申请人地址: Galleria Unione, 5 20122 Milano IT
- 专利权人: ROTTA RESEARCH LABORATORIUM S.P.A.
- 当前专利权人: ROTTA RESEARCH LABORATORIUM S.P.A.
- 当前专利权人地址: Galleria Unione, 5 20122 Milano IT
- 代理机构: Rambelli, Paolo (IT)
- 优先权: ITTO20001101 20010208
- 国际公布: WO02070468 20020912
- 主分类号: C07C279/36
- IPC分类号: C07C279/36 ; A61K31/155 ; A61P35/00 ; C07D213/40 ; C07C335/20 ; C07C257/14 ; C07C279/18 ; C07D209/42 ; C07D209/18
摘要:
Compounds which can be represented by the general formula (I) and in which A is selected independently from the carboxamide group, the thiocarboxamide group, and the carbonyl group, -R1 is selected from an alkyl group having from 1 to 3 carbon atoms and the amino group, unsubstituted or substituted with the nitro group or the methyl group, -R2 is selected independently from hydrogen, an alkyl group having from 1 to 4 carbon atoms, the methoxy, ethoxy, propoxy group, a mono-, bi- or tricyclic cycloalkane residue having from 5 to 12 carbon atoms, the adamantyl group, an aryl, naphthyl or heterocyclic group, unsubstituted or substituted with methyl, methoxy, hydroxy, amino or halogen groups, -R3 and R4 are selected independently from hydrogen and an alkyl group having from 1 to 3 carbon atoms, -R5 represents one or two substituents independently selected from hydrogen and the methyl, methoxyl, and hydroxyl groups, -n is a whole number from 0 to 6, and the amidine groups is in the para or meta position relative to the '-A-NH-' group.
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