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    SUBSTITUTED ARGININES AND SUBSTITUTED HOMOARGININES AND USE THEREOF
    3.
    发明授权
    SUBSTITUTED ARGININES AND SUBSTITUTED HOMOARGININES AND USE THEREOF 失效
    取代精氨酸和取代HOMO精氨酸和它们的用途

    公开(公告)号：EP0649303B1

    公开(公告)日：1998-11-25

    申请号：EP93913866.5

    申请日：1993-05-19

    申请人： CORNELL RESEARCH FOUNDATION, INC.

    发明人： GRIFFITH, Owen W.

    IPC分类号： A61K31/395 ,  C07C321/00 ,  C12N9/99 ,  C07C279/36 ,  C07C279/14

    CPC分类号： A61K31/195 ,  C07C279/14 ,  C07C279/36 ,  C07C281/16

    摘要： Guanidine substituted arginines or homoarginines based on monoalkyl carbon substituted ornithines or lysines, having formula (I) wherein R is (CH2)yCH3 or H, R' is CH2 or C(H)(CH2)yCH3, and R" is CH2 or C(H)(CH2)yCH3, with y ranging from 0 to 5, and x is 0 or 1 and Q is an alkyl group containing from 1 to 6 carbon atoms or NH2 or NO2, and only one of R, R' and R" providing an alkyl substituent on the ornithine or lysine moiety. A composition includes said compound together with a pharmaceutically acceptable carrier. Methods of use are directed to delivering said compound to inducible nitric oxide synthase to inhibit the ability of the enzyme to catalyze the conversion of arginine to nitric oxide, to administering said compound to inhibit pathological overproduction of nitric oxide from arginine and to administering said compound to a subject having systemic hypotension due to the pathological overproduction of nitric oxide and an alpha 1, adrenergic agonist to increase blood pressure in the subject to a clinically acceptable level.

    Verfahren zur Herstellung von N-Methyl-N'-nitroguanidin
    4.
    发明公开
    Verfahren zur Herstellung von N-Methyl-N'-nitroguanidin 失效
    Verfahren zur Herstellung von N-甲基-N'-硝基胍

    公开(公告)号：EP0798293A1

    公开(公告)日：1997-10-01

    申请号：EP97104120.7

    申请日：1997-03-12

    申请人： BAYER AG

    发明人： Gallenkamp, Bernd, Dr. ,  Rohe, Lothar, Dr.

    IPC分类号： C07C279/36

    CPC分类号： C07C279/36

    摘要： Die vorliegende Erfindung betrifft ein neues Verfahren zur Herstellung von N-Methyl-N'-nitroguanidin durch Umsetzung von Nitroguanidin mit wäßriger Methylaminlösung bei 0 bis 40°C.

    摘要翻译： 制备N-甲基-N'-硝基胍（I）的方法包括在0-40℃下使硝基胍（II）与甲胺水溶液反应：

    CONDENSED AMINO NITROGUANIDINE COMPOUNDS, SYNTHESIS AND USE AS BOTANICAL INSECTICIDES THEREOF
    8.
    发明公开
    CONDENSED AMINO NITROGUANIDINE COMPOUNDS, SYNTHESIS AND USE AS BOTANICAL INSECTICIDES THEREOF 有权
    Kondensierte Aminonitroguanidinzusammensetzungen，Synthese und Verwendung davon als botanische Insektizide

    公开(公告)号：EP2216324A1

    公开(公告)日：2010-08-11

    申请号：EP08877340.3

    申请日：2008-11-25

    申请人： Qin, ZhaoHai

    发明人： QIN, ZhaoHai ,  MA, Yongqiang ,  SU, Wangcang ,  WANG, Lei ,  ZHANG, Zheng ,  ZHAO, Bangbin ,  FANG, Jiangsheng

    IPC分类号： C07C281/18 ,  C07C279/36 ,  C07C277/08 ,  A01N47/44

    CPC分类号： C07C281/18 ,  A01N51/00

    摘要： The present invention discloses hydrocarbylidene nitrohydrozinecarboximidamides and the use thereof as well as a method for making the same. The structural general formula of the compounds are shown in formula I, wherein, R1 is C1 - C10 saturated and/or unsaturated aliphatic hydrocarbonyl, benzyl, substituted benzyl, halogenated picolyl, halogenated thiazolyl methyl, tetrahydrofuryl methyl or oxazolyl methyl; R2 is hydrogen, C1 - C5 saturated and/or unsaturated aliphatic hydrocarbonyl, phenyl, substituted phenyl, pyridyl or substituted pyridyl; R3 is hydrogen, C1 - C10 saturated and/or unsaturated aliphatic hydrocarbonyl, furyl, phenyl, substituted phenyl, benzyl or substituted benzyl. The tests of insecticidal activity show that the hydrocarbylidene nitrohydrozinecarboximidamides shown by formula (I) have high preventive efficiency against insect pests of plants, such as aphid, plant hopper, cotton bollworm, asparagus caterpillar, and the like, and can be used as plant insecticides.

    摘要翻译： 本发明公开了亚烃基硝基氢亚肟酰亚胺及其用途及其制备方法。 化合物的结构通式如式I所示，其中R1为C1-C10饱和和/或不饱和脂族烃基，苄基，取代苄基，卤代吡啶甲基，卤代噻唑基甲基，四氢呋喃基甲基或恶唑基甲基; R2是氢，C1-C5饱和和/或不饱和脂族烃基，苯基，取代的苯基，吡啶基或取代的吡啶基; R3是氢，C1-C10饱和和/或不饱和脂族烃基，呋喃基，苯基，取代的苯基，苄基或取代的苄基。 杀虫活性试验表明，式（I）所示的亚烃基硝基氢化胂甲酰胺对蚜虫，植物漏斗，棉铃虫，芦笋毛虫等植物的害虫具有较高的预防效果，可用作植物杀虫剂 。