发明公开
EP1379493A2 NON-IMIDAZOLE ARYL ALKYLAMINES COMPOUNDS AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES
审中-公开
非咪唑阿魏酸亚苄基维生素ALS组胺素H3抗抑郁药，HERSTELLUNG UND PHARMAZEUTISCHE VERWENDUNGEN
- 专利标题： NON-IMIDAZOLE ARYL ALKYLAMINES COMPOUNDS AS HISTAMINE H3 RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES
- 专利标题（中）： 非咪唑阿魏酸亚苄基维生素ALS组胺素H3抗抑郁药，HERSTELLUNG UND PHARMAZEUTISCHE VERWENDUNGEN
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申请号： EP02723329.5申请日： 2002-03-21
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公开(公告)号： EP1379493A2公开(公告)日： 2004-01-14
- 发明人: BEAVERS, Lisa, Selsam , GADSKI, Robert, Alan , HIPSKIND, Philip, Arthur , LINDSLEY, Craig, William , LOBB, Karen, Lynn , NIXON, James, Arthur , PICKARD, Richard, Todd , SCHAUS, John, Mehnert , TAKAKUWA, Takako , WATSON, Brian, Morgan
- 申请人： Eli Lilly and Company
- 申请人地址： Patent Division,P.O. Box 6288 Indianapolis, IN 46206-6288 US
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： Patent Division,P.O. Box 6288 Indianapolis, IN 46206-6288 US
- 代理机构： Burnside, Ivan John
- 优先权： US278230P 20010323
- 国际公布： WO2002076925 20021003
- 主分类号： C07C217/58
- IPC分类号： C07C217/58 ; A61K31/395 ; A61K31/131 ; A61P3/00 ; A61P25/00 ; C07D295/08 ; C07D295/12 ; C07C217/20 ; C07C311/05 ; C07C311/13 ; C07C311/18 ; C07C237/08 ; C07D295/14 ; C07C217/74 ; C07C271/34 ; C07C323/62 ; C07C271/24 ; C07C233/73 ; C07C237/32 ; C07C311/17 ; C07C409/12
摘要：
The present invention discloses novel substituted aryl alkylamine compounds of Formula (I) or pharmaceutically acceptable salts thereofwhich have selective histamine-H3 receptor antagonist activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such cyclic amines as well as methods of using them to treat obesity and other histamine H3 receptor -related diseases.
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