发明公开
EP1385820A1 ANTHRANILSÄUREAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS ANTIARRHYTHMIKA SOWIE PHARMAZEUTISCHE ZUBEREITUNGEN DAVON
有权
邻氨基，PROCESS FOR THEIR，它们的使用抗心律不齐药物及其制备物
- 专利标题： ANTHRANILSÄUREAMIDE, VERFAHREN ZU IHRER HERSTELLUNG, IHRE VERWENDUNG ALS ANTIARRHYTHMIKA SOWIE PHARMAZEUTISCHE ZUBEREITUNGEN DAVON
- 专利标题（英）： Anthranilic acid amides, method for the production thereof, their use as antiarrhythmia agents, and pharmaceutical preparations thereof
- 专利标题（中）： 邻氨基，PROCESS FOR THEIR，它们的使用抗心律不齐药物及其制备物
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申请号： EP02742898.6申请日： 2002-04-13
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公开(公告)号： EP1385820A1公开(公告)日： 2004-02-04
- 发明人: BRENDEL, Joachim , PIRARD, Bernard , PEUKERT, Stefan , KLEEMANN, Heinz-Werner , HEMMERLE, Horst
- 申请人： Aventis Pharma Deutschland GmbH
- 申请人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 专利权人： Aventis Pharma Deutschland GmbH
- 当前专利权人： Aventis Pharma Deutschland GmbH
- 当前专利权人地址： Brüningstrasse 50 65929 Frankfurt am Main DE
- 代理机构： Wein, Elmar Michael, Dr.
- 优先权： DE10121003 20010428
- 国际公布： WO2002088073 20021107
- 主分类号： C07C311/21
- IPC分类号： C07C311/21 ; C07C311/29 ; C07D213/56 ; C07C311/08 ; C07D233/64 ; C07D235/16 ; C07D307/54 ; C07D277/30 ; C07D215/14 ; C07D231/12 ; A61K31/18
摘要：
The invention relates to anthranilic acid amides, to a method for the production thereof, to their use as a medicament, and to pharmaceutical preparations containing these anthranilic acid amides. The anthranilic acid amides consist of compounds of formula (I) in which R(1) to (R7) have the meanings as cited in the claims, act upon the Kv1.5 potassium channel, and inhibit a potassium stream described as an 'ultra-rapidly activating delayed rectifier' in the human cardiac atrium. The compounds are therefore especially suited as novel antiarrhythmic active substances, particularly for treating and preventing atrial arrhythmias, e.g. atrial fibrillation AF or atrial flutter.
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