发明公开
EP1396496A1 NOVEL ASYMMETRICALLY BICIPITAL LIPID AND TUBULAR AGGREGATE FORMED BY USING THE SAME
有权
不相容，ZWEIKÖPFIGESLIPID UND MIT DIESEM GEBILDETESRÖHRENFÖRMIGESAGGREGAT
- 专利标题： NOVEL ASYMMETRICALLY BICIPITAL LIPID AND TUBULAR AGGREGATE FORMED BY USING THE SAME
- 专利标题（中）： 不相容，ZWEIKÖPFIGESLIPID UND MIT DIESEM GEBILDETESRÖHRENFÖRMIGESAGGREGAT
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申请号： EP02711287.9申请日： 2002-02-01
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公开(公告)号： EP1396496A1公开(公告)日： 2004-03-10
- 发明人: MASUDA, M., Tsukuba Cntr , SHIMIZU, T. Tsukuba Cntr
- 申请人： Japan Science and Technology Agency , National Institute of Advanced Industrial Science and Technology
- 申请人地址： 1-8, Hon-cho 4-chome Kawaguchi-shi, Saitama 332-0012 JP
- 专利权人： Japan Science and Technology Agency,National Institute of Advanced Industrial Science and Technology
- 当前专利权人： Japan Science and Technology Agency,National Institute of Advanced Industrial Science and Technology
- 当前专利权人地址： 1-8, Hon-cho 4-chome Kawaguchi-shi, Saitama 332-0012 JP
- 代理机构： Wilson Gunn Gee
- 优先权： JP2001129495 20010426
- 国际公布： WO2002090370 20021114
- 主分类号： C07H5/04
- IPC分类号： C07H5/04
摘要：
The present invention offers a novel asymmetric double-headed lipid capable of forming a stable, nanometer scale micro-tubular aggregated material of containing a sugar and a carboxylic acid at each end.
The present invention is an asymmetric double-headed lipid represented by the general formula
R-NHCO- (CH 2 ) n -COOH (I)
(in the formula, R represents an aldopyranose radical from which the terminal reducing hydroxyl group is excluded and n is from six to twenty) and a hollow micro-tubular aggregated material formed from the asymmetric double-headed lipid. The external diameter of the micro-tubular aggregated material is 10-300 nm, and the length is 0.3-10 µm. The micro-tubular aggregated material can be manufactured by dispersing the asymmetric double-headed lipid described above in water at pH of two to eight, next heating to 80-100°C to dissolve it and then gradually cooling the aqueous solution obtained.
The present invention is an asymmetric double-headed lipid represented by the general formula
R-NHCO- (CH 2 ) n -COOH (I)
(in the formula, R represents an aldopyranose radical from which the terminal reducing hydroxyl group is excluded and n is from six to twenty) and a hollow micro-tubular aggregated material formed from the asymmetric double-headed lipid. The external diameter of the micro-tubular aggregated material is 10-300 nm, and the length is 0.3-10 µm. The micro-tubular aggregated material can be manufactured by dispersing the asymmetric double-headed lipid described above in water at pH of two to eight, next heating to 80-100°C to dissolve it and then gradually cooling the aqueous solution obtained.
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