公开(公告)号：EP1396496B1

公开(公告)日：2010-09-15

申请号：EP02711287.9

申请日：2002-02-01

申请人： Japan Science and Technology Agency ,  National Institute of Advanced Industrial Science and Technology

发明人： MASUDA, M., Tsukuba Cntr ,  SHIMIZU, T. Tsukuba Cntr

IPC分类号： C07H13/06

CPC分类号： C07H5/04

公开(公告)号：EP1396496A1

公开(公告)日：2004-03-10

申请号：EP02711287.9

申请日：2002-02-01

申请人： Japan Science and Technology Agency ,  National Institute of Advanced Industrial Science and Technology

发明人： MASUDA, M., Tsukuba Cntr ,  SHIMIZU, T. Tsukuba Cntr

IPC分类号： C07H5/04

CPC分类号： C07H5/04

摘要： The present invention offers a novel asymmetric double-headed lipid capable of forming a stable, nanometer scale micro-tubular aggregated material of containing a sugar and a carboxylic acid at each end.
The present invention is an asymmetric double-headed lipid represented by the general formula

        R-NHCO- (CH 2 ) n -COOH     (I)

(in the formula, R represents an aldopyranose radical from which the terminal reducing hydroxyl group is excluded and n is from six to twenty) and a hollow micro-tubular aggregated material formed from the asymmetric double-headed lipid. The external diameter of the micro-tubular aggregated material is 10-300 nm, and the length is 0.3-10 µm. The micro-tubular aggregated material can be manufactured by dispersing the asymmetric double-headed lipid described above in water at pH of two to eight, next heating to 80-100°C to dissolve it and then gradually cooling the aqueous solution obtained.

摘要翻译： 本发明提供了一种新型的不对称双头脂质，其能够在每一端形成含有糖和羧酸的稳定的纳米级微管聚集物。 本发明是由通式R-NHCO-（CH2）n-COOH表示的不对称双头脂质（在该式中，R表示不包括末端还原羟基的醛吡喃基，n 为6至20个）和由不对称双头脂质形成的中空微管聚集物。 微管状聚集体的外径为10〜300nm，长度为0.3〜10μm。 微管状聚集体可以通过将上述不对称双头脂质分散在pH为2〜8的水中，接着加热至80-100℃，使其溶解，然后逐渐冷却所得水溶液。