发明公开
- 专利标题： 1,2,4-TRIOXOLANE ANTIMALARIALS
- 专利标题（中）： 1,2,4-三恶烷抗疟药
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申请号： EP02763208.2申请日： 2002-06-21
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公开(公告)号： EP1414813A1公开(公告)日： 2004-05-06
- 发明人: VENNERSTROM, J.,University of Nebraska Med. Ctr. , CHOLLET, Jacques,Pharma Research Department , DONG, Y.,University of Nebraska Medical Center , MATILE, Hugues,Pharma Research Department , PADMANILAYAM, M.,University of Nebraska Med. Ctr. , TANG, Y.,University of Nebraska Medical Center , CHARMAN, William N.,Victorian College of Pharmacy
- 申请人： Medicines for Malaria Venture
- 申请人地址： International Centre Cointrin,Entrance G,3rd Floor,Route de Pré-Bois 20,P.O. Box 1826 1215 Geneva 15 CH
- 专利权人： Medicines for Malaria Venture
- 当前专利权人： Medicines for Malaria Venture
- 当前专利权人地址： International Centre Cointrin,Entrance G,3rd Floor,Route de Pré-Bois 20,P.O. Box 1826 1215 Geneva 15 CH
- 代理机构： Tomkinson, Alex
- 优先权： US886666 20010621
- 国际公布： WO2003000676 20030103
- 主分类号： C07D323/02
- IPC分类号： C07D323/02 ; C07D493/10 ; C07D405/14 ; C07D405/08 ; C07D419/08 ; C07D521/00 ; A61P33/06
摘要：
A means and method for treating malaria using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl or spiropiperidyl ring on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably functionalized or substituted at the 4-position or a spiropiperidyl ring that is functionalized or substituted at the nitrogen atom. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
公开/授权文献
- EP1414813B1 1,2,4-TRIOXOLANE ANTIMALARIALS 公开/授权日：2006-09-13
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