公开(公告)号：EP3022200B1

公开(公告)日：2017-03-01

申请号：EP14759317.2

申请日：2014-07-17

申请人： MMV Medicines for Malaria Venture ,  Drexel University ,  University of Washington

发明人： BURROWS, Jeremy ,  WYVRATT, Matthew ,  VAIDYA, Akhil ,  KORTAGERE, Sandhya ,  FAN, Erkang ,  CHATTERJEE, Arnab Kumar ,  NAGLE, Advait Suresh ,  KATO, Tomoyo

IPC分类号： C07D403/12 ,  C07D231/40 ,  A61K31/415 ,  A61K31/4184 ,  A61P33/06

CPC分类号： C07D231/40 ,  A61K31/415 ,  A61K31/4184 ,  A61K45/06 ,  C07D403/12

公开(公告)号：EP3118198A1

公开(公告)日：2017-01-18

申请号：EP15176514.6

申请日：2015-07-13

申请人： MMV Medicines for Malaria Venture ,  University Of Cape Town

发明人： WATERSON, David ,  WITTY, Michael John ,  CHIBALE, Kelly ,  STREET, Leslie ,  GONZALEZ CABRERA, Diego ,  PAQUET, Tanya

IPC分类号： C07D401/04 ,  A61K31/4965 ,  A61K31/497 ,  C07D241/20 ,  A61P33/06

CPC分类号： C07D241/20 ,  A61K31/4965 ,  A61K31/497 ,  A61K45/06 ,  A61P33/06 ,  C07D401/04 ,  Y02A50/411 ,  A61K2300/00

摘要： The present invention is related to a use of aminopyrazine derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to aminopyrazine derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

摘要翻译： 本发明涉及氨基吡嗪衍生物在制备用于预防或治疗疟疾的药物中的用途。 具体地，本发明涉及可用于制备用于抑制疟疾寄生虫增殖的药物制剂的氨基吡嗪衍生物。

公开(公告)号：EP2203457B1

公开(公告)日：2014-03-05

申请号：EP08845311.3

申请日：2008-10-29

申请人： MMV Medicines for Malaria Venture

发明人： VENNERSTROM, Jonathan, L. ,  DONG, Yuxiang ,  CHARMAN, Susan, A. ,  WITTLIN, Sergio ,  CHOLLET, Jacques ,  CREEK, Darren, J. ,  WANG, Xiaofang ,  SRIRAGHAVAN, Kamaraj ,  ZHOU, Lin ,  MATILE, Hugues ,  CHARMAN, William, N.

IPC分类号： C07D493/10 ,  A61K31/343 ,  A61K31/4525 ,  A61K31/496 ,  A61P33/06 ,  A61K31/553 ,  A61K31/5377 ,  A61K31/541

CPC分类号： C07D493/10 ,  C07D323/02 ,  C07D405/12 ,  C07D413/12

公开(公告)号：EP2203457A2

公开(公告)日：2010-07-07

申请号：EP08845311.3

申请日：2008-10-29

申请人： Medicines For Malaria Venture MMV

发明人： VENNERSTROM, Jonathan, L. ,  DONG, Yuxiang ,  CHARMAN, Susan, A. ,  WITTLIN, Sergio ,  CHOLLET, Jacques ,  CREEK, Darren, J. ,  WANG, Xiaofang ,  SRIRAGHAVAN, Kamaraj ,  ZHOU, Lin ,  MATILE, Hugues ,  CHARMAN, William, N.

IPC分类号： C07D493/10 ,  A61K31/343 ,  A61K31/4525 ,  A61K31/496 ,  A61P33/06 ,  A61K31/553 ,  A61K31/5377 ,  A61K31/541

CPC分类号： C07D493/10 ,  C07D323/02 ,  C07D405/12 ,  C07D413/12

摘要： A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites. The compounds of the invention unexpectedly provide a single-dose cure for malaria, as well as prophylactic activity against the same. The compounds are also active against schistosomiasis and cancer.

公开(公告)号：EP3526214A1

公开(公告)日：2019-08-21

申请号：EP17783836.4

申请日：2017-10-12

申请人： MMV Medicines for Malaria Venture

发明人： VENNERSTROM, Jonathan L. ,  CHARMAN, Susan A.

IPC分类号： C07D405/12 ,  A61K31/4525 ,  A61P33/06

公开(公告)号：EP3309156A1

公开(公告)日：2018-04-18

申请号：EP16193814.7

申请日：2016-10-13

申请人： MMV Medicines for Malaria Venture

发明人： VENNERSTROM, Jonathan Lee ,  CHARMAN, Susan Ann

IPC分类号： C07D405/12 ,  A61K31/4525 ,  A61P33/06

CPC分类号： C07D405/12

摘要： The present invention is related to new trioxolane derivatives of formula (I) in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to trioxolane derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

摘要翻译： 本发明涉及式（I）的新型三氧戊环衍生物在制备用于预防或治疗疟疾的药物中的用途。 具体而言，本发明涉及可用于制备抑制疟疾寄生虫增殖的药物制剂的三氧杂环戊烷衍生物。

公开(公告)号：EP1514871B1

公开(公告)日：2015-10-21

申请号：EP04254821.4

申请日：2004-08-11

申请人： MMV Medicines for Malaria Venture

发明人： Vennerstrom, Jonathan L., Univ.of Nebraska Med. C. ,  Tang, Yuanquing, University of Nebraska Medic.Cen. ,  Dong, Yuxiang University of Nebraska Medic.Center ,  Matile, Hughes, Pharma Research Department, ,  Charman, William N., Victorian College of Pharmacy ,  Chollet, Jaques, Swiss Tropical Institute ,  Padmanilayam, Maniyan ,  Yatendra, Kumar ,  Gyan, Chand Yadav

IPC分类号： C07D405/12 ,  C07D323/02 ,  C07D417/06 ,  C07D405/06 ,  A61P33/06 ,  A61K31/357

CPC分类号： C07D405/06 ,  A61K31/335 ,  A61K31/4747 ,  C07D323/02 ,  C07D405/12 ,  C07D417/06 ,  Y02A50/411 ,  Y02A50/423

摘要： A means and method for treating malaria, schistosomiasis, and cancer using a dispiro 1,2,4-trioxolane is described. The 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.

公开(公告)号：EP2483274B1

公开(公告)日：2014-10-29

申请号：EP10821105.3

申请日：2010-09-28

申请人： Board of Regents, The University of Texas System ,  Monash University ,  MMV Medicines for Malaria Venture ,  University of Washington ,  Glaxosmithkline Investigacion y Desarrollo, S.L.

发明人： RATHOD, Pradipsinh, K. ,  FLOYD, David ,  BURROWS, Jeremy ,  MARWAHA, Alka ,  GUJJAR, Ramesh ,  COTERON-LOPEZ, Jose ,  PHILLIPS, Margaret ,  CHARMAN, Susan, A. ,  MATTHEWS, David

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P33/06

CPC分类号： C07D487/04

公开(公告)号：EP2483274A2

公开(公告)日：2012-08-08

申请号：EP10821105.3

申请日：2010-09-28

申请人： Board of Regents, The University of Texas System ,  Monash University ,  Medicines For Malaria Venture ,  University of Washington ,  Glaxosmithkline Investigacion y Desarrollo, S.L.

发明人： RATHOD, Pradipsinh, K. ,  FLOYD, David ,  BURROWS, Jeremy ,  MARWAHA, Alka ,  GUJJAR, Ramesh ,  COTERON-LOPEZ, Jose ,  PHILLIPS, Margaret ,  CHARMAN, Susan, A. ,  MATTHEWS, David

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P33/06

CPC分类号： C07D487/04

摘要： Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula (IX): and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.

公开(公告)号：EP4077308B1

公开(公告)日：2024-02-14

申请号：EP20830210.9

申请日：2020-12-18

发明人： PHILLIPS, Margaret ,  PALMER, Michael ,  CHARMAN, Susan A. ,  WATTS, Karl, Shawn ,  GERASYUTO, Aleksey I. ,  KRILOV, Goran

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D413/14 ,  A61K31/4439 ,  A61K31/4196 ,  A61P33/06 ,  C07D207/34