发明公开
- 专利标题： FXR NR1H4 NUCLEAR RECEPTOR BINDING COMPOUNDS
- 专利标题（中）： 去核FXR NR1H4受体结合的化合物
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申请号： EP02750472.9申请日： 2002-08-13
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公开(公告)号： EP1423370A1公开(公告)日： 2004-06-02
- 发明人: BAUER, Ulrike , CHERUVALLATH, Zach , DEUSCHLE, Ulrich , DNEPROVSKAIA, Elena , GAHMAN, Tim , GIEGRICH, Kristina , HANECAK, Ronnie , HEBERT, Normand , KIELY, John , KOBER, Ingo , KOGL, Manfred , KRANZ, Harald , KREMOSER, Claus , LEE, Matthew , OTTE, Kerstin , SAGE, Carlton , SUD, Manish
- 申请人： LION bioscience AG
- 申请人地址： Waldhofer Strasse 98 69123 Heidelberg DE
- 专利权人： LION bioscience AG
- 当前专利权人： LION bioscience AG
- 当前专利权人地址： Waldhofer Strasse 98 69123 Heidelberg DE
- 代理机构： Krauss, Jan B., Dr.
- 优先权： EP01119473 20010813
- 国际公布： WO2003016288 20030227
- 主分类号： C07D239/42
- IPC分类号： C07D239/42 ; A61K31/506 ; A61P3/04 ; A61P9/00 ; A61P35/00
摘要：
The invention provides compounds according to the general formula (1) which bind to the NR1H4 receptor and act as agonists, antagonists or mixed agonists/antagonists of the NR1H4 receptor. The invention further provides methods of treating diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compouds.
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