公开(公告)号：EP1423370A1

公开(公告)日：2004-06-02

申请号：EP02750472.9

申请日：2002-08-13

申请人： LION bioscience AG

发明人： BAUER, Ulrike ,  CHERUVALLATH, Zach ,  DEUSCHLE, Ulrich ,  DNEPROVSKAIA, Elena ,  GAHMAN, Tim ,  GIEGRICH, Kristina ,  HANECAK, Ronnie ,  HEBERT, Normand ,  KIELY, John ,  KOBER, Ingo ,  KOGL, Manfred ,  KRANZ, Harald ,  KREMOSER, Claus ,  LEE, Matthew ,  OTTE, Kerstin ,  SAGE, Carlton ,  SUD, Manish

IPC分类号： C07D239/42 ,  A61K31/506 ,  A61P3/04 ,  A61P9/00 ,  A61P35/00

CPC分类号： C07D261/08 ,  C07B2200/11 ,  C07D213/74 ,  C07D239/42 ,  C07D409/04

摘要： The invention provides compounds according to the general formula (1) which bind to the NR1H4 receptor and act as agonists, antagonists or mixed agonists/antagonists of the NR1H4 receptor. The invention further provides methods of treating diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compouds.

公开(公告)号：EP1423113A1

公开(公告)日：2004-06-02

申请号：EP02750474.5

申请日：2002-08-13

申请人： LION bioscience AG

发明人： BAUER, Ulrike ,  CHERUVALLATH, Zach ,  DEUSCHLE, Ulrich ,  DNEPROVSKAIA, Elena ,  GAHMAN, Tim ,  GIEGRICH, Kristina ,  HANECAK, Ronnie ,  HEBERT, Normand ,  KIELY, John ,  KOBER, Ingo ,  KOGL, Manfred ,  KRANZ, Harald ,  KREMOSER, Claus ,  LEE, Matthew ,  OTTE, Kerstin ,  SAGE, Carlton ,  SUD, Manish

IPC分类号： A61K31/426 ,  C07D277/40 ,  C07D277/42 ,  C07D277/44 ,  C07D277/46

CPC分类号： C07D277/42 ,  C07B2200/11 ,  C07D277/52

摘要： The present invention relates to compounds according to the general formula (I) which bind to the NR1H4 receptor and act as agonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compounds.

公开(公告)号：EP1423111A1

公开(公告)日：2004-06-02

申请号：EP02750473.7

申请日：2002-08-13

申请人： LION bioscience AG

发明人： BAUER, Ulrike ,  CHERUVALLATH, Zach ,  DEUSCHLE, Ulrich ,  DNEPROVSKAIA, Elena ,  GAHMAN, Tim ,  GIEGRICH, Kristina ,  HANECAK, Ronnie ,  HEBERT, Normand ,  KIELY, John ,  KOBER, Ingo ,  KOGL, Manfred ,  KRANZ, Harald ,  KREMOSER, Claus ,  LEE, Matthew ,  OTTE, Kerstin ,  SAGE, Carlton ,  SUD, Manish

IPC分类号： A61K31/42 ,  C07D261/08

CPC分类号： C07D261/08 ,  C07B2200/11 ,  C07D213/74 ,  C07D239/42 ,  C07D409/04

摘要： The present invention relates to compounds according to the general formula (I) which bind to the nuclear receptor, NR1H4, and act as agonists, antagonists or mixed agonists / antagonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds.