公开(公告)号：EP1317542A2

公开(公告)日：2003-06-11

申请号：EP01982261.8

申请日：2001-09-07

申请人： LION Bioscience AG

发明人： CASARI, Georg ,  HÖFER, Michael ,  JACKSON, David ,  KRANZ, Harald ,  OTTE, Kerstin ,  REMMEL, Bettina ,  SUCKOW, Jörg

IPC分类号： C12N15/12 ,  C07K14/705 ,  C12N5/10 ,  G01N33/68 ,  C07K16/28 ,  C12Q1/68 ,  C12N15/11 ,  A61K48/00 ,  A61K39/395 ,  A61K31/7088

CPC分类号： C07K14/70567 ,  A61K38/00 ,  A61K48/00

摘要： The present invention relates to a novel nuclear receptor called 'L66' or also FXR-β a homologue of the FXR-α, a prototypical type 2 nuclear receptor. The invention also relates to the isolated nucleic acid sequence of L66 and the isolated protein thereof. The invention further relates to processes for isolating and/or producing the nucleic acid or the protein as well as methods of use of the receptor L66.

摘要翻译： 本发明涉及称为'L66'的新型核受体或FXR-α（原型2型核受体）的同系物FXR-β。 本发明还涉及L66的分离的核酸序列及其分离的蛋白质。 本发明还涉及用于分离和/或生产核酸或蛋白质的方法以及受体L66的使用方法。

公开(公告)号：EP1423370A1

公开(公告)日：2004-06-02

申请号：EP02750472.9

申请日：2002-08-13

申请人： LION bioscience AG

发明人： BAUER, Ulrike ,  CHERUVALLATH, Zach ,  DEUSCHLE, Ulrich ,  DNEPROVSKAIA, Elena ,  GAHMAN, Tim ,  GIEGRICH, Kristina ,  HANECAK, Ronnie ,  HEBERT, Normand ,  KIELY, John ,  KOBER, Ingo ,  KOGL, Manfred ,  KRANZ, Harald ,  KREMOSER, Claus ,  LEE, Matthew ,  OTTE, Kerstin ,  SAGE, Carlton ,  SUD, Manish

IPC分类号： C07D239/42 ,  A61K31/506 ,  A61P3/04 ,  A61P9/00 ,  A61P35/00

CPC分类号： C07D261/08 ,  C07B2200/11 ,  C07D213/74 ,  C07D239/42 ,  C07D409/04

摘要： The invention provides compounds according to the general formula (1) which bind to the NR1H4 receptor and act as agonists, antagonists or mixed agonists/antagonists of the NR1H4 receptor. The invention further provides methods of treating diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compouds.

公开(公告)号：EP1423113A1

公开(公告)日：2004-06-02

申请号：EP02750474.5

申请日：2002-08-13

申请人： LION bioscience AG

发明人： BAUER, Ulrike ,  CHERUVALLATH, Zach ,  DEUSCHLE, Ulrich ,  DNEPROVSKAIA, Elena ,  GAHMAN, Tim ,  GIEGRICH, Kristina ,  HANECAK, Ronnie ,  HEBERT, Normand ,  KIELY, John ,  KOBER, Ingo ,  KOGL, Manfred ,  KRANZ, Harald ,  KREMOSER, Claus ,  LEE, Matthew ,  OTTE, Kerstin ,  SAGE, Carlton ,  SUD, Manish

IPC分类号： A61K31/426 ,  C07D277/40 ,  C07D277/42 ,  C07D277/44 ,  C07D277/46

CPC分类号： C07D277/42 ,  C07B2200/11 ,  C07D277/52

摘要： The present invention relates to compounds according to the general formula (I) which bind to the NR1H4 receptor and act as agonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compounds.

公开(公告)号：EP1423111A1

公开(公告)日：2004-06-02

申请号：EP02750473.7

申请日：2002-08-13

申请人： LION bioscience AG

发明人： BAUER, Ulrike ,  CHERUVALLATH, Zach ,  DEUSCHLE, Ulrich ,  DNEPROVSKAIA, Elena ,  GAHMAN, Tim ,  GIEGRICH, Kristina ,  HANECAK, Ronnie ,  HEBERT, Normand ,  KIELY, John ,  KOBER, Ingo ,  KOGL, Manfred ,  KRANZ, Harald ,  KREMOSER, Claus ,  LEE, Matthew ,  OTTE, Kerstin ,  SAGE, Carlton ,  SUD, Manish

IPC分类号： A61K31/42 ,  C07D261/08

CPC分类号： C07D261/08 ,  C07B2200/11 ,  C07D213/74 ,  C07D239/42 ,  C07D409/04

摘要： The present invention relates to compounds according to the general formula (I) which bind to the nuclear receptor, NR1H4, and act as agonists, antagonists or mixed agonists / antagonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through binding of the nuclear receptor by the compounds.