发明授权
- 专利标题： VERFAHREN ZUR GROSSTECHNISCHEN HERSTELLUNG VON IMPFSTOFFEN
- 专利标题（英）： Methods for the industrial production of vaccines
- 专利标题（中）： 方法疫苗的工业化生产
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申请号： EP02777069.2申请日： 2002-09-11
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公开(公告)号： EP1427815B1公开(公告)日： 2010-09-01
- 发明人: VORLOP, Jürgen , Frech, Christian , LÜBBEN, Holger , GREGERSEN, Jens-Peter
- 申请人： Novartis Vaccines and Diagnostics GmbH
- 申请人地址： Emil-von-Behring-Strasse 76 35041 Marburg DE
- 专利权人： Novartis Vaccines and Diagnostics GmbH
- 当前专利权人： Novartis Vaccines and Diagnostics GmbH
- 当前专利权人地址： Emil-von-Behring-Strasse 76 35041 Marburg DE
- 代理机构： UEXKÜLL & STOLBERG
- 优先权： DE10144906 20010912
- 国际公布： WO2003023021 20030320
- 主分类号： C12N5/07
- IPC分类号： C12N5/07 ; C12N7/00 ; A61K39/12 ; A61P31/12
摘要：
The invention relates to methods for producing an active constituent of a pharmaceutical or a diagnostic agent, whereby (a) MDCK cells are infected with a virus, and (b) said MDCK cells are cultivated in a suspension culture on a technical scale and under conditions which enable viruses to multiply, the cultivation being carried out in a volume of at least 30 L. The invention also relates to methods for producing a pharmaceutical or a diagnostic agent, whereby an active constituent is produced according to one of the abovementioned methods and is mixed with a suitable adjuvant, auxiliary agent, buffer solution, diluting agent or pharmaceutical carrier.
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