发明公开
- 专利标题: HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS OF THE URINARY TRACT
- 专利标题(中): 杂环化合物尿路的治疗
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申请号: EP02782863.1申请日: 2002-10-07
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公开(公告)号: EP1432701A1公开(公告)日: 2004-06-30
- 发明人: LEONARDI, Amedeo , MOTTA, Gianni , RIVA, Carlo , TESTA, Rodolfo , CORBETT, Jeff, W.
- 申请人: RECORDATI S.A.CHEMICAL and PHARMACEUTICAL COMPANY , RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.
- 申请人地址: Piazza Boffalora 4 6830 Chiasso CH
- 专利权人: RECORDATI S.A.CHEMICAL and PHARMACEUTICAL COMPANY,RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.
- 当前专利权人: RECORDATI S.A.CHEMICAL and PHARMACEUTICAL COMPANY,RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.
- 当前专利权人地址: Piazza Boffalora 4 6830 Chiasso CH
- 代理机构: McKelvey, Ian Edward
- 优先权: ITMI20012060 20011005
- 国际公布: WO2003031436 20030417
- 主分类号: C07D401/12
- IPC分类号: C07D401/12 ; A61K31/47 ; A61K31/404 ; A61P13/00 ; C07D215/12 ; C07D215/18 ; C07D215/20 ; C07D405/12 ; C07D215/40 ; C07D215/42 ; C07D215/26 ; C07D401/06 ; C07D417/12 ; C07D413/12 ; C07D409/08 ; C07D413/08 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D409/14
摘要:
Compounds of formula (I) are thus useful for treating disorders of the urinary tract. In the compounds I, R1 = one or more substituents selected from H, halogen, OH, alkyl, haloalkyl, alkoxy, haloalkoxy, NO2, nitro, phenyl, substituted phenyl, heterocycle, substituted heterocycle, NR3R4(R3 and R4 being H, alkyl, acyl or alkoxycarbonyl); R2 = one or two substituents selected from H, alkyl; Y = CH2 or a bond; Q = CO, CS or SO2; A = alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heterocyclic, alkylamino, dialkylamino, arylamino or arylalkylamino, each of which is optionally substituted; n is 1 or 2; X = an amino moiety selected from formula (a), (b) and -N(R5)-CH2-(R5 = H, methyl, benzyl group; W = bond, N, CH, CH2, C(CN) C(OH) or C(COCH3) (when W represents a nitrogen atom or a CH, C(CN) C(OH) or C(COCH3) group, the group Z-B attaches to the W ring atom); when X is (a) or (b), Z = bond, O, S, CH2, CH2CH2, CO, CHOH, OCH2, NH, NHCO or NHCONHCH2, but when X is -N(R5)-CH2-group, Z represents a CH2CH2 or CH2O group or Z and B together represent a 2,3-dihydro-benzo[1,4]dioxin-2-yl group; and B is a monocyclic or bicyclic aryl group or a monocyclic or bicyclic heterocycle, each of which is optionally substituted.
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