发明授权
EP1444215B1 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS
有权
1,2,4-噻二唑衍生物作为黑色素受体调节剂
- 专利标题： 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS
- 专利标题（中）： 1,2,4-噻二唑衍生物作为黑色素受体调节剂
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申请号： EP02778727.4申请日： 2002-11-05
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公开(公告)号： EP1444215B1公开(公告)日： 2006-07-19
- 发明人: EISINGER, Magdalena , FITZPATRICK, Louis, J. , LEE, Daniel, H. , PAN, Kevin , PLATA-SALAMAN, Carlos , REITZ, Allen, B. , SMITH-SWINTOSKY, Virginia, L. , ZHAO, Boyu
- 申请人： Ortho-McNeil Pharmaceutical, Inc.
- 申请人地址： U.S. Route No.202 Raritan, NJ 08869-0602 US
- 专利权人： Ortho-McNeil Pharmaceutical, Inc.
- 当前专利权人： Ortho-McNeil Pharmaceutical, Inc.
- 当前专利权人地址： U.S. Route No.202 Raritan, NJ 08869-0602 US
- 代理机构： Mercer, Christopher Paul
- 优先权： US337762P 20011108
- 国际公布： WO2003040118 20030515
- 主分类号： C07D285/08
- IPC分类号： C07D285/08 ; C07D417/12 ; A61K31/433 ; A61P3/00 ; A61P17/00 ; A61P25/00
摘要：
The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives of the formula (I); wherein R?1, R2 and R4¿ are ring containing radicals, R3 is H, alkyl, alkenyl or alkynyl, useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatement of metabolic, CNS and dermatological disorders.
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