公开(公告)号：EP1446394B1

公开(公告)日：2006-11-02

申请号：EP02776448.9

申请日：2002-11-04

申请人： Ortho-McNeil Pharmaceutical, Inc.

发明人： EISINGER, Magdalena ,  FITZPATRICK, Louis, J. ,  LEE, Daniel, H. ,  PAN, Kevin ,  PLATA-SALAMAN, Carlos ,  REITZ, Allen, B. ,  SMITH-SWINTOSKY, Virginia, L. ,  ZHAO, Boyu

IPC分类号： C07D285/08 ,  C07D417/12 ,  A61K31/433 ,  A61P3/00 ,  A61P17/00 ,  A61P25/00

CPC分类号： C07D285/08 ,  A61K8/49 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/007 ,  C07D417/12

摘要： The present invention is directed to novel 1,2,4-thiadiazole derivatives of the formula (II) wherein R1, R2 and R4, are ring containing radicals, useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders.

公开(公告)号：EP1444215B1

公开(公告)日：2006-07-19

申请号：EP02778727.4

申请日：2002-11-05

申请人： Ortho-McNeil Pharmaceutical, Inc.

发明人： EISINGER, Magdalena ,  FITZPATRICK, Louis, J. ,  LEE, Daniel, H. ,  PAN, Kevin ,  PLATA-SALAMAN, Carlos ,  REITZ, Allen, B. ,  SMITH-SWINTOSKY, Virginia, L. ,  ZHAO, Boyu

IPC分类号： C07D285/08 ,  C07D417/12 ,  A61K31/433 ,  A61P3/00 ,  A61P17/00 ,  A61P25/00

CPC分类号： C07D285/08 ,  A61K8/49 ,  A61Q5/006 ,  A61Q19/00 ,  A61Q19/007 ,  C07D333/16 ,  C07D417/12 ,  C07F9/4018

摘要： The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives of the formula (I); wherein R?1, R2 and R4¿ are ring containing radicals, R3 is H, alkyl, alkenyl or alkynyl, useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatement of metabolic, CNS and dermatological disorders.

摘要翻译： 本发明涉及式（I）的新型1,2,4-噻二唑-2-鎓衍生物; 其中R 1，R 2和R 4'是含有基团的环，R 3是H，烷基，烯基或炔基，用作黑皮质素受体的激动剂或拮抗剂。 更具体地说，本发明的化合物可用于治疗代谢，CNS和皮肤疾病。