发明公开
EP1465925A2 ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO TRAIL RECEPTORS
审中-公开
“抗体，该抗体特异性免疫对TRAIL？受体的结合”
- 专利标题： ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO TRAIL RECEPTORS
- 专利标题（中）： “抗体，该抗体特异性免疫对TRAIL？受体的结合”
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申请号： EP02797420.3申请日： 2002-12-19
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公开(公告)号： EP1465925A2公开(公告)日： 2004-10-13
- 发明人: SALCEDO, Theodora , ALBERT, Vivian, R. , ROSEN, Craig, A. , HUMPHREYS, Robin , VAUGHAN, Tristan, John
- 申请人： Human Genome Sciences, Inc.
- 申请人地址： 14200 Shady Grove Road Rockville, MD 20850 US
- 专利权人： Human Genome Sciences, Inc.
- 当前专利权人： Human Genome Sciences, Inc.
- 当前专利权人地址： 14200 Shady Grove Road Rockville, MD 20850 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US341237P 20011220; US369877P 20020405; US384828P 20020604; US396591P 20020718; US403370P 20020815; US425737P 20021113
- 国际公布： WO2003054216 20030703
- 主分类号： C07K16/00
- IPC分类号： C07K16/00
摘要：
The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR7. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR7 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR7.
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