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公开(公告)号：EP1572874A2
公开(公告)日：2005-09-14
申请号：EP02736661.6
申请日：2002-05-07
发明人： SALCEDO, Theodora , RUBEN, Steven, M. , ROSEN, Craig, A. , ALBERT, Vivian, R. , DOBSON, Clarie Louise , VAUGHAN, Tristan John
IPC分类号： C12N1/00
CPC分类号： C07K16/30 , A61K31/00 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/2878 , C07K2317/565 , C07K2317/622 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors, and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating, or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
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公开(公告)号：EP1385864B1
公开(公告)日：2010-06-09
申请号：EP02726730.1
申请日：2002-04-12
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
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公开(公告)号：EP1572874A3
公开(公告)日：2005-12-07
申请号：EP02736661.6
申请日：2002-05-07
发明人： SALCEDO, Theodora , RUBEN, Steven, M. , ROSEN, Craig, A. , ALBERT, Vivian, R. , DOBSON, Clarie Louise , VAUGHAN, Tristan John
IPC分类号： C12N1/00
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公开(公告)号：EP1633316A2
公开(公告)日：2006-03-15
申请号：EP04775943.6
申请日：2004-05-05
发明人： SALCEDO, Theodora , ROSEN, Craig, A. , ALBERT, Vivian, R. , HUMPHREYS, Robin , VAUGHAN, Tristan, John
IPC分类号： A61K8/18
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/30 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/30
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR7. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR7 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR7.
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公开(公告)号：EP1497445A2
公开(公告)日：2005-01-19
申请号：EP03714458.1
申请日：2003-03-28
IPC分类号： C12P21/08 , G01N33/53 , A61K39/395 , A61K39/40 , A61K39/42
CPC分类号： A61K51/1018 , A61K47/6843 , A61K2039/505 , C07K16/18 , C07K16/26 , C07K2317/21 , C07K2317/56 , C07K2317/622
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to GMAD. Such antibodies have uses, for example, in the prevention and treatment of both insulin- and non insulin-dependent diabetes mellitus (i.e. Type I and Type II diabetes) and other related disorders. The invention also relates to nucleic acid molecules encoding anti-GMAD antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially diabetes and other related disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to GMAD.
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公开(公告)号：EP1465925A2
公开(公告)日：2004-10-13
申请号：EP02797420.3
申请日：2002-12-19
发明人： SALCEDO, Theodora , ALBERT, Vivian, R. , ROSEN, Craig, A. , HUMPHREYS, Robin , VAUGHAN, Tristan, John
IPC分类号： C07K16/00
CPC分类号： A61K45/06 , A61K2039/505 , C07K16/2878 , C07K16/30 , C07K2317/565 , C07K2317/622 , C07K2317/73
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR7. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR7 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR7.
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公开(公告)号：EP1385864A1
公开(公告)日：2004-02-04
申请号：EP02726730.1
申请日：2002-04-12
CPC分类号： C07K16/22 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/52 , C07K16/24 , C07K2317/21 , C07K2317/622 , C12N2799/026 , G01N33/574 , G01N33/74 , Y02A50/41 , Y02A50/422 , Y10S435/81
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
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公开(公告)号：EP1385862A2
公开(公告)日：2004-02-04
申请号：EP02721715.7
申请日：2002-04-12
CPC分类号： C07K14/52
摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.
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