发明公开
EP1485492A2 GNTIII (UDP-N-ACETYLGLUCOSAMINE:BETA-D MANNOSIDE BETA(1,4)-N-ACETYLGLUCOSAMINYLTRANSFERASE III) EXPRESSION IN PLANTS
有权
GNTIII（UDP-N-乙酰谷氨酰胺：BET-D-MANNOSID-BETA（1,4）-N-乙酰胆碱氨基转移酶III）PFLANZEN中的表达
- 专利标题： GNTIII (UDP-N-ACETYLGLUCOSAMINE:BETA-D MANNOSIDE BETA(1,4)-N-ACETYLGLUCOSAMINYLTRANSFERASE III) EXPRESSION IN PLANTS
- 专利标题（中）： GNTIII（UDP-N-乙酰谷氨酰胺：BET-D-MANNOSID-BETA（1,4）-N-乙酰胆碱氨基转移酶III）PFLANZEN中的表达
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申请号： EP03715213.9申请日： 2003-03-18
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公开(公告)号： EP1485492A2公开(公告)日： 2004-12-15
- 发明人: BAKKER, Hendrikus, Antonius, Cornelus , FLORACK, Dionisius, Elisabeth, Antonius , BOSCH, Hendrik, Jan
- 申请人： Plant Research International B.V.
- 申请人地址： Droevendaalsesteeg 1 6708 PB Wageningen NL
- 专利权人： Plant Research International B.V.
- 当前专利权人： Plant Research International B.V.
- 当前专利权人地址： Droevendaalsesteeg 1 6708 PB Wageningen NL
- 代理机构： Marshall, Cameron John
- 优先权： US365769P 20020319; US368047P 20020326
- 国际公布： WO2003078614 20030925
- 主分类号： C12N15/82
- IPC分类号： C12N15/82
摘要：
The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTII (EC 2.4.1.144)l that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.
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