发明公开
- 专利标题： ANGIOGENESIS INHIBITORS
- 专利标题（中）： 血管生成抑制剂
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申请号： EP03710259.7申请日： 2003-03-06
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公开(公告)号： EP1489186A1公开(公告)日： 2004-12-22
- 发明人: KUMAGAI, Hiroyuki , SAMESHIMA, Tomohiro , MATSUFUJI, Motoko , KAWAMURA, Naoto , SOMENO, Tetsuya , ISHIZUKA, Masaaki , TAKEUCHI, Tomio
- 申请人： MERCIAN CORPORATION , ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 申请人地址： 5-8, Kyobashi 1-chome Chuo-ku, Tokyo 104-8305 JP
- 专利权人： MERCIAN CORPORATION,ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 当前专利权人： MERCIAN CORPORATION,ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 当前专利权人地址： 5-8, Kyobashi 1-chome Chuo-ku, Tokyo 104-8305 JP
- 代理机构： Horner, Martin Grenville
- 优先权： JP2002063059 20020308
- 国际公布： WO2003076638 20030918
- 主分类号： C12P17/02
- IPC分类号： C12P17/02 ; C07D493/04 ; C07D303/32 ; A61P17/06 ; A61P27/02 ; A61P29/00 ; A61P35/00 ; A61P43/00
摘要：
Compounds represented by formula (I) below; a process for producing the compounds by culturing a microorganism belonging to the genus Aspergillus and isolating the above-mentioned compounds from the culture; an angiogenesis inhibitory agent containing as an active ingredient the compounds; and an Aspergillus sp. F-1491 (FERM BP-8288) strain capable of producing the compounds.
In formula (I), R represents a methyl group or an ethyl group, R 1 represents a hydrogen atom, a chlorine atom, a hydroxyl group or a methoxy group, R 2 represents a hydroxyl group, or R 1 and R 2 taken together form an epoxy ring structure.
In formula (I), R represents a methyl group or an ethyl group, R 1 represents a hydrogen atom, a chlorine atom, a hydroxyl group or a methoxy group, R 2 represents a hydroxyl group, or R 1 and R 2 taken together form an epoxy ring structure.
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