发明公开
- 专利标题： SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE
- 专利标题（中）： 取代的吡啶酮为P38 MAP激酶调
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申请号： EP03713478.0申请日： 2003-02-14
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公开(公告)号： EP1490064A1公开(公告)日： 2004-12-29
- 发明人: DEVADAS, Balekudru , WALKER, John , SELNESS, Shaun, R. , BOEHM, Terri, L. , DURLEY, Richard, C. , DEVRAJ, Rajesh , HICKORY, Brian, S. , RUCKER, Paul, V. , JEROME, Kevin, D. , MADSEN, Heather, M. , ALVIRA, Edgardo , PROMO, Michele, A. , BLEVIS-BAL, Radhika, M. , MARRUFO, Laura, D. , HITCHCOCK, Jeff , OWEN, Thomas , NAING, Win , XING, Li , SHIEH, Huey, S. , LIU, Shuang , SCOTT, Ian, L. , SAMBANDAM, Aruna , MCGEE, Kevin F.
- 申请人： Pharmacia Corporation
- 申请人地址： 800 North Lindbergh Boulevard St. Louis, MO 63167 US
- 专利权人： Pharmacia Corporation
- 当前专利权人： Pharmacia Corporation
- 当前专利权人地址： 800 North Lindbergh Boulevard St. Louis, MO 63167 US
- 代理机构： Dekker, Henrike Cornelie Christine
- 优先权： US357029P 20020214; US436915P 20021230
- 国际公布： WO2003068230 20030821
- 主分类号： A61K31/4412
- IPC分类号： A61K31/4412 ; A61P29/00 ; C07D213/69 ; C07D401/06 ; C07D409/06 ; C07D213/70 ; C07D213/64 ; C07D213/74 ; C07D405/06 ; C07D213/84 ; C07D401/10 ; C07D405/12 ; C07D401/12 ; C07D213/75 ; C07D401/14 ; C07D213/79 ; C07D401/04 ; C07D405/04 ; C07D413/10 ; C07D215/22 ; C07D405/14
摘要：
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
公开/授权文献
- EP1490064B1 SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE 公开/授权日：2009-11-18
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