公开(公告)号：EP1490064B1

公开(公告)日：2009-11-18

申请号：EP03713478.0

申请日：2003-02-14

申请人： Pharmacia Corporation

发明人： DEVADAS, Balekudru ,  WALKER, John ,  SELNESS, Shaun, R. ,  BOEHM, Terri, L. ,  DURLEY, Richard, C. ,  DEVRAJ, Rajesh ,  HICKORY, Brian, S. ,  RUCKER, Paul, V. ,  JEROME, Kevin, D. ,  MADSEN, Heather, M. ,  ALVIRA, Edgardo ,  PROMO, Michele, A. ,  BLEVIS-BAL, Radhika, M. ,  MARRUFO, Laura, D. ,  HITCHCOCK, Jeff ,  OWEN, Thomas ,  NAING, Win ,  XING, Li ,  SHIEH, Huey, S. ,  LIU, Shuang ,  SCOTT, Ian, L. ,  SAMBANDAM, Aruna ,  MCGEE, Kevin F.

IPC分类号： A61K31/4412 ,  A61P29/00 ,  C07D213/69 ,  C07D401/06 ,  C07D409/06 ,  C07D213/70 ,  C07D213/64 ,  C07D213/74 ,  C07D405/06 ,  C07D213/84 ,  C07D401/10 ,  C07D405/12 ,  C07D401/12 ,  C07D213/75 ,  C07D401/14 ,  C07D213/79 ,  C07D401/04 ,  C07D405/04 ,  C07D413/10 ,  C07D215/22 ,  C07D405/14

CPC分类号： C07D213/64 ,  C07D213/69 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D213/79 ,  C07D213/84 ,  C07D213/85 ,  C07D215/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D413/10

摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.

公开(公告)号：EP1490064A1

公开(公告)日：2004-12-29

申请号：EP03713478.0

申请日：2003-02-14

申请人： Pharmacia Corporation

发明人： DEVADAS, Balekudru ,  WALKER, John ,  SELNESS, Shaun, R. ,  BOEHM, Terri, L. ,  DURLEY, Richard, C. ,  DEVRAJ, Rajesh ,  HICKORY, Brian, S. ,  RUCKER, Paul, V. ,  JEROME, Kevin, D. ,  MADSEN, Heather, M. ,  ALVIRA, Edgardo ,  PROMO, Michele, A. ,  BLEVIS-BAL, Radhika, M. ,  MARRUFO, Laura, D. ,  HITCHCOCK, Jeff ,  OWEN, Thomas ,  NAING, Win ,  XING, Li ,  SHIEH, Huey, S. ,  LIU, Shuang ,  SCOTT, Ian, L. ,  SAMBANDAM, Aruna ,  MCGEE, Kevin F.

IPC分类号： A61K31/4412 ,  A61P29/00 ,  C07D213/69 ,  C07D401/06 ,  C07D409/06 ,  C07D213/70 ,  C07D213/64 ,  C07D213/74 ,  C07D405/06 ,  C07D213/84 ,  C07D401/10 ,  C07D405/12 ,  C07D401/12 ,  C07D213/75 ,  C07D401/14 ,  C07D213/79 ,  C07D401/04 ,  C07D405/04 ,  C07D413/10 ,  C07D215/22 ,  C07D405/14

CPC分类号： C07D213/64 ,  C07D213/69 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D213/79 ,  C07D213/84 ,  C07D213/85 ,  C07D215/22 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D413/10

摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.