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公开(公告)号：EP1490064B1
公开(公告)日：2009-11-18
申请号：EP03713478.0
申请日：2003-02-14
发明人： DEVADAS, Balekudru , WALKER, John , SELNESS, Shaun, R. , BOEHM, Terri, L. , DURLEY, Richard, C. , DEVRAJ, Rajesh , HICKORY, Brian, S. , RUCKER, Paul, V. , JEROME, Kevin, D. , MADSEN, Heather, M. , ALVIRA, Edgardo , PROMO, Michele, A. , BLEVIS-BAL, Radhika, M. , MARRUFO, Laura, D. , HITCHCOCK, Jeff , OWEN, Thomas , NAING, Win , XING, Li , SHIEH, Huey, S. , LIU, Shuang , SCOTT, Ian, L. , SAMBANDAM, Aruna , MCGEE, Kevin F.
IPC分类号： A61K31/4412 , A61P29/00 , C07D213/69 , C07D401/06 , C07D409/06 , C07D213/70 , C07D213/64 , C07D213/74 , C07D405/06 , C07D213/84 , C07D401/10 , C07D405/12 , C07D401/12 , C07D213/75 , C07D401/14 , C07D213/79 , C07D401/04 , C07D405/04 , C07D413/10 , C07D215/22 , C07D405/14
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
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2.发明公开ACYCLIC PYRAZOLE COMPOUNDS FOR THE INHIBITION OF MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 审中-公开无环吡唑抑制蛋白激酶活化丝裂原活化蛋白激酶2的
公开(公告)号：EP1572682A2
公开(公告)日：2005-09-14
申请号：EP03814309.5
申请日：2003-12-19
发明人： HANAU, Cathleen, E. , MERSHON, Serena, Marie , GRANETO, Matthew, J. , MEYERS, Marvin, J. , HEGDE, Shridhar, G. , BUCHLER, Ingrid, P. , WU, Kun, K. , LIU, Shuang , NACRO, Kassoom
IPC分类号： C07D401/14
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D471/14 , C07D487/04 , C07D513/04 , C07D519/00
摘要： Compounds are described which inhibit mitogen activated protein kinase-activated protein kinase-2 (MK-2). Methods of making such compounds are described, as well as a method of using them for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNFα, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.
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公开(公告)号：EP1490064A1
公开(公告)日：2004-12-29
申请号：EP03713478.0
申请日：2003-02-14
发明人： DEVADAS, Balekudru , WALKER, John , SELNESS, Shaun, R. , BOEHM, Terri, L. , DURLEY, Richard, C. , DEVRAJ, Rajesh , HICKORY, Brian, S. , RUCKER, Paul, V. , JEROME, Kevin, D. , MADSEN, Heather, M. , ALVIRA, Edgardo , PROMO, Michele, A. , BLEVIS-BAL, Radhika, M. , MARRUFO, Laura, D. , HITCHCOCK, Jeff , OWEN, Thomas , NAING, Win , XING, Li , SHIEH, Huey, S. , LIU, Shuang , SCOTT, Ian, L. , SAMBANDAM, Aruna , MCGEE, Kevin F.
IPC分类号： A61K31/4412 , A61P29/00 , C07D213/69 , C07D401/06 , C07D409/06 , C07D213/70 , C07D213/64 , C07D213/74 , C07D405/06 , C07D213/84 , C07D401/10 , C07D405/12 , C07D401/12 , C07D213/75 , C07D401/14 , C07D213/79 , C07D401/04 , C07D405/04 , C07D413/10 , C07D215/22 , C07D405/14
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
摘要： Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
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