发明公开
EP1498411A4 DIKETOHYDRAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT
有权
DIZETHYDRAZINDERIVATVERBINDUNGEN UND ARZNEIMITTEL，DIE DIE VERBINDUNGEN ALS WIRKSTOFF ENTHALTEN
- 专利标题： DIKETOHYDRAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT
- 专利标题（中）： DIZETHYDRAZINDERIVATVERBINDUNGEN UND ARZNEIMITTEL，DIE DIE VERBINDUNGEN ALS WIRKSTOFF ENTHALTEN
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申请号： EP03723188申请日： 2003-04-24
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公开(公告)号： EP1498411A4公开(公告)日： 2005-11-30
- 发明人: HATAYAMA AKIRA , TSURUTA HIROSHI , OCHI YASUO , IMAWAKA HARUO , OHMOTO KAZUYUKI
- 申请人： ONO PHARMACEUTICAL CO
- 专利权人： ONO PHARMACEUTICAL CO
- 当前专利权人： ONO PHARMACEUTICAL CO
- 优先权： JP2002123796 2002-04-25
- 主分类号： C07C243/24
- IPC分类号： C07C243/24 ; A61K31/16 ; A61K31/165 ; A61K31/341 ; A61K31/351 ; A61K31/40 ; A61K31/4025 ; A61K31/4035 ; A61K31/4152 ; A61K31/4166 ; A61K31/4168 ; A61K31/421 ; A61K31/423 ; A61K31/425 ; A61K31/426 ; A61K31/427 ; A61K31/428 ; A61K31/429 ; C07C243/34 ; C07C251/76 ; C07C251/84 ; C07C251/86 ; C07D207/22 ; C07D207/50 ; C07D209/46 ; C07D209/48 ; C07D211/28 ; C07D211/72 ; C07D211/86 ; C07D211/98 ; C07D213/70 ; C07D213/76 ; C07D213/77 ; C07D213/78 ; C07D233/38 ; C07D233/52 ; C07D233/80 ; C07D239/10 ; C07D239/18 ; C07D239/36 ; C07D241/08 ; C07D241/18 ; C07D263/26 ; C07D263/28 ; C07D265/08 ; C07D265/10 ; C07D265/32 ; C07D265/33 ; C07D275/02 ; C07D275/03 ; C07D275/06 ; C07D277/18 ; C07D277/36 ; C07D277/50 ; C07D277/54 ; C07D277/60 ; C07D277/82 ; C07D279/02 ; C07D279/06 ; C07D279/12 ; C07D285/10 ; C07D285/16 ; C07D309/04 ; C07D309/28 ; C07D335/04 ; C07D401/12 ; C07D403/12 ; C07D405/12 ; C07D409/12 ; C07D417/12 ; C07D513/10 ; C07F9/59 ; C07F9/6558 ; C07D207/408 ; C07D211/26 ; C07D213/53 ; C07D231/08 ; C07D233/32 ; C07D307/52 ; C07D309/06 ; C07D413/12 ; C07D487/04
摘要：
The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification). The compound of formula (I) has an inhibitory activity against cysteine protease, and it is useful for the treatment of inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, neuronal diseases, hepatic or biliary diseases, osseous or articular diseases, metabolic diseases, etc. And the compound has inhibitory activity against elastase and it is also useful for the treatment of COPD (chronic obstacle pulmonary diseases).
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