发明公开
EP1507767A1 4-SUBSTITUTED IMIDAZOLE-2-THIONES AND IMIDAZOL-2-ONES AS AGONISTS OF THE ALPHA-2B AND ALPHA-2C ADRENERGIC RECEPTORS
审中-公开
4-取代的咪唑-2-硫酮和咪唑-2-酮作为ALPHA-2B肾上腺素受体和α-2C的激动剂
- 专利标题： 4-SUBSTITUTED IMIDAZOLE-2-THIONES AND IMIDAZOL-2-ONES AS AGONISTS OF THE ALPHA-2B AND ALPHA-2C ADRENERGIC RECEPTORS
- 专利标题（中）： 4-取代的咪唑-2-硫酮和咪唑-2-酮作为ALPHA-2B肾上腺素受体和α-2C的激动剂
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申请号： EP03738924.4申请日： 2003-05-16
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公开(公告)号： EP1507767A1公开(公告)日： 2005-02-23
- 发明人: CHOW, Ken , HEIDELBAUGH, Todd , GIL, Daniel , GARST, Michael , WHEELER, Larry, A. , NGUYEN, Phong, X. , GOMEZ, Dario, G.
- 申请人： Allergan, Inc.
- 申请人地址： 2525 Dupont Drive Irvine,California 92612 US
- 专利权人： Allergan, Inc.
- 当前专利权人： Allergan, Inc.
- 当前专利权人地址： 2525 Dupont Drive Irvine,California 92612 US
- 代理机构： HOFFMANN EITLE
- 优先权： US153328 20020521
- 国际公布： WO2003099795 20031204
- 主分类号： C07D233/84
- IPC分类号： C07D233/84 ; C07D233/70 ; A61K31/4164 ; A61K31/4166 ; C07D409/06 ; C07D401/06 ; C07D405/06 ; C07D409/08 ; A61K31/4178
摘要：
Compounds of Formula (I): where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula (I) are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula (I) where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.
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