公开(公告)号：EP1185539B1

公开(公告)日：2004-12-01

申请号：EP00941321.2

申请日：2000-06-09

申请人： Allergan, Inc.

发明人： BEARD, Richard, L. ,  GARST, Michael ,  CHANDRARATNA, Roshantha, A.

IPC分类号： C07F7/08

CPC分类号： C07F7/0807 ,  C07F7/0814 ,  C07F7/0818

摘要： Silicon-containing organic compounds useful as modulators of mammalian nuclear hormone receptors, particularly the retinoid receptors and the farnesoid receptors.

摘要翻译： 有机硅有机化合物可用作哺乳动物核激素受体的调节剂，特别是类视黄醇受体和法呢基受体。

公开(公告)号：EP1507767A1

公开(公告)日：2005-02-23

申请号：EP03738924.4

申请日：2003-05-16

申请人： Allergan, Inc.

发明人： CHOW, Ken ,  HEIDELBAUGH, Todd ,  GIL, Daniel ,  GARST, Michael ,  WHEELER, Larry, A. ,  NGUYEN, Phong, X. ,  GOMEZ, Dario, G.

IPC分类号： C07D233/84 ,  C07D233/70 ,  A61K31/4164 ,  A61K31/4166 ,  C07D409/06 ,  C07D401/06 ,  C07D405/06 ,  C07D409/08 ,  A61K31/4178

CPC分类号： C07D401/06 ,  C07D233/70 ,  C07D233/84 ,  C07D405/06 ,  C07D409/06 ,  C07D409/08

摘要： Compounds of Formula (I): where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula (I) are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula (I) where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.