发明公开
- 专利标题： BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
- 专利标题（中）： 双环吡唑有效的激酶抑制剂，用于生产和含有药物组合物
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申请号： EP03738106.8申请日： 2003-07-01
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公开(公告)号： EP1526852A1公开(公告)日： 2005-05-04
- 发明人: VILLA, Manuela , ABRATE, Francesca , FANCELLI, Daniele , VARASI, Mario , VULPETTI, Anna
- 申请人： Pharmacia Italia S.p.A.
- 申请人地址： Via Robert Koch 1.2 20152 Milano IT
- 专利权人： Pharmacia Italia S.p.A.
- 当前专利权人： Pharmacia Italia S.p.A.
- 当前专利权人地址： Via Robert Koch 1.2 20152 Milano IT
- 代理机构： Modiano, Micaela Nadia
- 优先权： US398122P 20020725
- 国际公布： WO2004014374 20040219
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; A61P25/28 ; A61P35/00 ; C07D471/04
摘要：
The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a pyrazole-tetrahydro pyridine derivative. The invention also provides specific pyrazole-tetrahydro pyridines, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.
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